Amrubicin induces apoptosis in human tumor cells mediated by the activation of caspase‐3/7 preceding a loss of mitochondrial membrane potential

Amrubicin, a completely synthetic 9‐aminoanthracycline derivative, inhibits cell growth by stabilizing a topoisomerase II–DNA complex. This study was designed to examine the apoptosis induced in human leukemia U937 cells by amrubicin and its active metabolite amrubicinol. Amrubicin, amrubicinol and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 2006-12, Vol.97 (12), p.1396-1403
Hauptverfasser:	Hanada, Mitsuharu, Noguchi, Toshihiro, Yamaoka, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracyclines - pharmacology Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Biological and medical sciences Caspase 3 - metabolism Caspase 7 - metabolism Cell Division - drug effects Daunorubicin - pharmacology Drug Therapy, Combination Enzyme Activation - drug effects Etoposide - pharmacology G2 Phase - drug effects General aspects Humans Medical sciences Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - metabolism Original Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects Tumors U937 Cells
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!