15‐Lipoxygenase‐1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT‐116 and HT‐29

Colorectal carcinoma (CRC) is often lethal when invasion and/or metastasis occur. 15‐Lipoxygenase‐1 (15‐LO‐1), a member of the inflammatory eicosanoid pathway, oxidatively metabolizes linoleic acid and its expression is repressed in CRC. In this study, we investigated the hypothesis that the lack of...

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Veröffentlicht in:	Cancer science 2009-12, Vol.100 (12), p.2283-2291
Hauptverfasser:	Çimen, Ismail, Tunçay, Seda, Banerjee, Sreeparna
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Arachidonate 15-Lipoxygenase - genetics Arachidonate 15-Lipoxygenase - physiology Cell Movement Cell Proliferation Colorectal Neoplasms - enzymology Colorectal Neoplasms - pathology HCT116 Cells Histone Deacetylases - physiology Humans Linoleic Acids - biosynthesis Neoplasm Invasiveness Neoplasm Metastasis Original Repressor Proteins - physiology Trans-Activators
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