HLA class I antigen expression is associated with a favorable prognosis in early stage non‐small cell lung cancer
Human leukocyte antigen (HLA) class I displays a repertoire of endogenously processed peptides to CD8+ T lymphocytes. The present study assessed correlations between HLA class I expression, clinicopathologic factors, and tumor‐infiltrating immune cells in human non‐small cell lung cancers (NSCLC). E...
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| Veröffentlicht in: | Cancer science 2007-09, Vol.98 (9), p.1424-1430 |
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| creator | Kikuchi, Eiki Yamazaki, Koichi Torigoe, Toshihiko Cho, Yasushi Miyamoto, Masaki Oizumi, Satoshi Hommura, Fumihiro Dosaka‐Akita, Hirotoshi Nishimura, Masaharu |
| description | Human leukocyte antigen (HLA) class I displays a repertoire of endogenously processed peptides to CD8+ T lymphocytes. The present study assessed correlations between HLA class I expression, clinicopathologic factors, and tumor‐infiltrating immune cells in human non‐small cell lung cancers (NSCLC). Expression of HLA class I was assessed in 161 resected primary NSCLC by immunohistochemistry using EMR8–5, a novel monoclonal anti‐pan HLA class I heavy chain antibody. Expression of HLA class I was classified into three categories: strongly positive, weakly positive, or negative. Tumor‐infiltrating CD8+ lymphocytes and CD56+ natural killer cells within cancer nests and stroma were also counted. Expression of HLA class I was strongly positive in 50 tumors, weakly positive in 57 tumors, and negative in 54 tumors. Down‐regulation of HLA class I was significantly correlated with male sex, history of smoking, non‐adenocarcinoma histology, and moderate‐/low‐grade differentiation. The density of cancer nest‐infiltrating CD8+ cells in HLA class I‐negative tumors was significantly decreased compared to that in HLA class I strongly positive tumors (P |
| doi_str_mv | 10.1111/j.1349-7006.2007.00558.x |
| format | Article |
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The present study assessed correlations between HLA class I expression, clinicopathologic factors, and tumor‐infiltrating immune cells in human non‐small cell lung cancers (NSCLC). Expression of HLA class I was assessed in 161 resected primary NSCLC by immunohistochemistry using EMR8–5, a novel monoclonal anti‐pan HLA class I heavy chain antibody. Expression of HLA class I was classified into three categories: strongly positive, weakly positive, or negative. Tumor‐infiltrating CD8+ lymphocytes and CD56+ natural killer cells within cancer nests and stroma were also counted. Expression of HLA class I was strongly positive in 50 tumors, weakly positive in 57 tumors, and negative in 54 tumors. Down‐regulation of HLA class I was significantly correlated with male sex, history of smoking, non‐adenocarcinoma histology, and moderate‐/low‐grade differentiation. The density of cancer nest‐infiltrating CD8+ cells in HLA class I‐negative tumors was significantly decreased compared to that in HLA class I strongly positive tumors (P < 0.01). Kaplan–Meier analysis revealed a significant favorable influence on overall survival for patients displaying tumors with strongly positive expression of HLA class I (P < 0.01). Multivariate analysis revealed down‐regulation of HLA class I as an independent factor of poor prognosis in pathological stage I patients, but not in late‐stage patients. These results suggest that down‐regulation of HLA class I expression in NSCLC is a marker of poor prognosis, and this may play a critical role in immune surveillance of patients with NSCLC. 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The present study assessed correlations between HLA class I expression, clinicopathologic factors, and tumor‐infiltrating immune cells in human non‐small cell lung cancers (NSCLC). Expression of HLA class I was assessed in 161 resected primary NSCLC by immunohistochemistry using EMR8–5, a novel monoclonal anti‐pan HLA class I heavy chain antibody. Expression of HLA class I was classified into three categories: strongly positive, weakly positive, or negative. Tumor‐infiltrating CD8+ lymphocytes and CD56+ natural killer cells within cancer nests and stroma were also counted. Expression of HLA class I was strongly positive in 50 tumors, weakly positive in 57 tumors, and negative in 54 tumors. Down‐regulation of HLA class I was significantly correlated with male sex, history of smoking, non‐adenocarcinoma histology, and moderate‐/low‐grade differentiation. The density of cancer nest‐infiltrating CD8+ cells in HLA class I‐negative tumors was significantly decreased compared to that in HLA class I strongly positive tumors (P < 0.01). Kaplan–Meier analysis revealed a significant favorable influence on overall survival for patients displaying tumors with strongly positive expression of HLA class I (P < 0.01). Multivariate analysis revealed down‐regulation of HLA class I as an independent factor of poor prognosis in pathological stage I patients, but not in late‐stage patients. These results suggest that down‐regulation of HLA class I expression in NSCLC is a marker of poor prognosis, and this may play a critical role in immune surveillance of patients with NSCLC. 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Yamazaki, Koichi ; Torigoe, Toshihiko ; Cho, Yasushi ; Miyamoto, Masaki ; Oizumi, Satoshi ; Hommura, Fumihiro ; Dosaka‐Akita, Hirotoshi ; Nishimura, Masaharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5868-434f1f4f76a5c283e0bb230226b64f158f1abf22bf68d437fd30daa14ebae7983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>beta 2-Microglobulin - biosynthesis</topic><topic>beta 2-Microglobulin - genetics</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - immunology</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic - immunology</topic><topic>Histocompatibility Antigens Class I - biosynthesis</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>HLA Antigens - biosynthesis</topic><topic>HLA Antigens - genetics</topic><topic>HLA Antigens - immunology</topic><topic>Humans</topic><topic>Lung Neoplasms - immunology</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymphocytes, Tumor-Infiltrating - immunology</topic><topic>Lymphocytes, Tumor-Infiltrating - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Original</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kikuchi, Eiki</creatorcontrib><creatorcontrib>Yamazaki, Koichi</creatorcontrib><creatorcontrib>Torigoe, Toshihiko</creatorcontrib><creatorcontrib>Cho, Yasushi</creatorcontrib><creatorcontrib>Miyamoto, Masaki</creatorcontrib><creatorcontrib>Oizumi, Satoshi</creatorcontrib><creatorcontrib>Hommura, Fumihiro</creatorcontrib><creatorcontrib>Dosaka‐Akita, Hirotoshi</creatorcontrib><creatorcontrib>Nishimura, Masaharu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kikuchi, Eiki</au><au>Yamazaki, Koichi</au><au>Torigoe, Toshihiko</au><au>Cho, Yasushi</au><au>Miyamoto, Masaki</au><au>Oizumi, Satoshi</au><au>Hommura, Fumihiro</au><au>Dosaka‐Akita, Hirotoshi</au><au>Nishimura, Masaharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA class I antigen expression is associated with a favorable prognosis in early stage non‐small cell lung cancer</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2007-09</date><risdate>2007</risdate><volume>98</volume><issue>9</issue><spage>1424</spage><epage>1430</epage><pages>1424-1430</pages><issn>1347-9032</issn><eissn>1349-7006</eissn><abstract>Human leukocyte antigen (HLA) class I displays a repertoire of endogenously processed peptides to CD8+ T lymphocytes. The present study assessed correlations between HLA class I expression, clinicopathologic factors, and tumor‐infiltrating immune cells in human non‐small cell lung cancers (NSCLC). Expression of HLA class I was assessed in 161 resected primary NSCLC by immunohistochemistry using EMR8–5, a novel monoclonal anti‐pan HLA class I heavy chain antibody. Expression of HLA class I was classified into three categories: strongly positive, weakly positive, or negative. Tumor‐infiltrating CD8+ lymphocytes and CD56+ natural killer cells within cancer nests and stroma were also counted. Expression of HLA class I was strongly positive in 50 tumors, weakly positive in 57 tumors, and negative in 54 tumors. Down‐regulation of HLA class I was significantly correlated with male sex, history of smoking, non‐adenocarcinoma histology, and moderate‐/low‐grade differentiation. The density of cancer nest‐infiltrating CD8+ cells in HLA class I‐negative tumors was significantly decreased compared to that in HLA class I strongly positive tumors (P < 0.01). Kaplan–Meier analysis revealed a significant favorable influence on overall survival for patients displaying tumors with strongly positive expression of HLA class I (P < 0.01). Multivariate analysis revealed down‐regulation of HLA class I as an independent factor of poor prognosis in pathological stage I patients, but not in late‐stage patients. These results suggest that down‐regulation of HLA class I expression in NSCLC is a marker of poor prognosis, and this may play a critical role in immune surveillance of patients with NSCLC. (Cancer Sci 2007; 98: 1424–1430)</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>17645781</pmid><doi>10.1111/j.1349-7006.2007.00558.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged beta 2-Microglobulin - biosynthesis beta 2-Microglobulin - genetics Biological and medical sciences Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Female Gene Expression Regulation, Neoplastic - immunology Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology HLA Antigens - biosynthesis HLA Antigens - genetics HLA Antigens - immunology Humans Lung Neoplasms - immunology Lung Neoplasms - mortality Lung Neoplasms - pathology Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Male Medical sciences Original Pneumology Prognosis Retrospective Studies Tumors Tumors of the respiratory system and mediastinum |
| title | HLA class I antigen expression is associated with a favorable prognosis in early stage non‐small cell lung cancer |
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