Antitumor effect of MCC‐465, pegylated liposomal doxorubicin tagged with newly developed monoclonal antibody GAH, in colorectal cancer xenografts

MCC‐465 is an immunoliposome‐encapsulated doxorubicin. The liposome is tagged with polyethylene glycol and the F(ab)2 of a monoclonal antibody named GAH, a human antibody obtained by the hybridoma technique. The epitope recognized by GAH is not well characterized, but human gastric, colorectal, and...

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Veröffentlicht in:	Cancer science 2004-07, Vol.95 (7), p.608-613
Hauptverfasser:	Hamaguchi, Tetsuya, Matsumura, Yasuhiro, Nakanishi, Yukihiro, Muro, Kei, Yamada, Yasuhide, Shimada, Yasuhiro, Shirao, Kuniaki, Niki, Hisae, Hosokawa, Saiko, Tagawa, Toshiaki, Kakizoe, Tadao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antitumor activity Biological and medical sciences Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - veterinary Doxorubicin Doxorubicin - pharmacology Epitopes Fab Gastroenterology. Liver. Pancreas. Abdomen Humans Hybridomas Liposomes Male Medical sciences Metastases Mice Mice, Inbred BALB C Monoclonal antibodies Polyethylene glycol Polyethylene Glycols - pharmacology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transplantation, Heterologous Tumors Xenografts
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