Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte‐derived heregulin

To study the mechanisms of the highly liver‐metastatic character of colon carcinoma cells, we studied the expression pattern of surface integrins on LS‐LM6 (a highly liver‐metastatic human colon cancer cell line) and the effects of hepatocyte‐derived soluble factors on cell migration. LS‐LM6 showed...

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Veröffentlicht in:	Cancer science 2010-09, Vol.101 (9), p.2011-2018
Hauptverfasser:	Yoshioka, Toshiaki, Nishikawa, Yuji, Ito, Reiko, Kawamata, Makiko, Doi, Yuko, Yamamoto, Yohei, Yoshida, Masayuki, Omori, Yasufumi, Kotanagi, Hitoshi, Masuko, Takashi, Enomoto, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Cells, Cultured Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Culture Media, Conditioned - metabolism Culture Media, Conditioned - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Hepatocytes - metabolism Humans Immunohistochemistry Integrin alpha5beta1 - genetics Integrin alpha5beta1 - metabolism Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - secondary Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Mice, SCID Neoplasms, Experimental - genetics Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neuregulin-1 - metabolism Neuregulin-1 - pharmacology Original Phosphorylation - drug effects Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - genetics Receptor, ErbB-3 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Transplantation, Heterologous Tumors
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