Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis

The focus of the present study was whether and how infiltrating macrophages play a role in angiogenesis and the growth of cancer cells in response to the inflammatory cytokine interleukin (IL)‐1β. Lewis lung carcinoma cells overexpressing IL‐1β grew faster and induced greater neovascularization than...

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Veröffentlicht in:	Cancer science 2007-12, Vol.98 (12), p.2009-2018
Hauptverfasser:	Kimura, Yusuke N., Watari, Kosuke, Fotovati, Abbas, Hosoi, Fumihito, Yasumoto, Kosei, Izumi, Hiroto, Kohno, Kimitoshi, Umezawa, Kazuo, Iguchi, Haruo, Shirouzu, Kazuo, Takamori, Sinzo, Kuwano, Michihiko, Ono, Mayumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - drug effects Cell Line, Tumor Clodronic Acid - pharmacology Drug Synergism Humans Inflammation - physiopathology Interleukin-1beta - pharmacology Lung Neoplasms - pathology Macrophages - physiology Male Medical sciences Mice Mice, Inbred C57BL Neoplasms - blood supply Neoplasms - pathology Neovascularization, Pathologic - pathology Original /Reports Transplantation, Heterologous Tumors U937 Cells
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