Human mesenchymal stem cells promote growth of osteosarcoma: Involvement of interleukin‐6 in the interaction between human mesenchymal stem cells and Saos‐2

Our previous study showed that exogenous human mesenchymal stem cells (hMSCs) targeted established osteosarcoma and promoted its growth and pulmonary metastasis in vivo. As a follow‐up, the present study aimed to investigate how hMSCs would interact with Saos‐2 through autocrine/paracrine communicat...

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Veröffentlicht in:	Cancer science 2010-12, Vol.101 (12), p.2554-2560
Hauptverfasser:	Bian, Zhen‐Yu, Fan, Qi‐Ming, Li, Gang, Xu, Wen‐Ting, Tang, Ting‐Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - metabolism Bone Neoplasms - pathology Cancer Cell Communication - physiology Cell Differentiation - physiology Cell Line, Tumor Communication Data processing Differentiation Enzyme-Linked Immunosorbent Assay Feedback Humans Interleukin 6 Interleukin-6 - biosynthesis Lung Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Metastases Mice Mice, Nude Original Osteogenesis Osteosarcoma Osteosarcoma - metabolism Osteosarcoma - pathology RNA, Small Interfering - genetics Stem cells Tibia Tumors Xenograft Model Antitumor Assays
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