Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
Head and neck cancer (HNC) is one of the 10 most frequent cancers worldwide, with an estimated over 500 000 new cases being diagnosed annually. The overall 5‐year survival rate in patients with HNC is one of the lowest among common malignant neoplasms and has not significantly changed during the las...
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| Veröffentlicht in: | Cancer science 2008-08, Vol.99 (8), p.1507-1514 |
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| creator | Chen, Yin‐Ju Chang, Joseph Tung‐Chieh Liao, Chun‐Ta Wang, Hung‐Ming Yen, Tzu‐Chen Chiu, Ching‐Chi Lu, Ya‐Ching Li, Hsiao‐Fang Cheng, Ann‐Joy |
| description | Head and neck cancer (HNC) is one of the 10 most frequent cancers worldwide, with an estimated over 500 000 new cases being diagnosed annually. The overall 5‐year survival rate in patients with HNC is one of the lowest among common malignant neoplasms and has not significantly changed during the last two decades. Oral cavity squamous cell carcinoma (OSCC) shares part of HNC and has been reported to be increasing in the betel quid chewing area in recent years. During 2006, OSCC has become the sixth most common type of cancer in Taiwan, and it is also the fourth most common type of cancer among men. It follows that this type of cancer wreaks a high social and personal cost. Environmental carcinogens such as betel quid chewing, tobacco smoking and alcohol drinking have been identified as major risk factors for head and neck cancer. There is growing interest in understanding the relationship between genetic susceptibility and the prevalent environmental carcinogens for HNC prevention. Within this review, we discuss the molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area. Knowledge of molecular carcinogenesis of HNC may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics. (Cancer Sci 2008; 99: 1507–1514) |
| doi_str_mv | 10.1111/j.1349-7006.2008.00863.x |
| format | Article |
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The overall 5‐year survival rate in patients with HNC is one of the lowest among common malignant neoplasms and has not significantly changed during the last two decades. Oral cavity squamous cell carcinoma (OSCC) shares part of HNC and has been reported to be increasing in the betel quid chewing area in recent years. During 2006, OSCC has become the sixth most common type of cancer in Taiwan, and it is also the fourth most common type of cancer among men. It follows that this type of cancer wreaks a high social and personal cost. Environmental carcinogens such as betel quid chewing, tobacco smoking and alcohol drinking have been identified as major risk factors for head and neck cancer. There is growing interest in understanding the relationship between genetic susceptibility and the prevalent environmental carcinogens for HNC prevention. Within this review, we discuss the molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area. Knowledge of molecular carcinogenesis of HNC may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics. (Cancer Sci 2008; 99: 1507–1514)</description><identifier>ISSN: 1347-9032</identifier><identifier>ISSN: 1349-7006</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2008.00863.x</identifier><identifier>PMID: 18754860</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adult ; Alcohol Drinking - adverse effects ; Areca - adverse effects ; Biological and medical sciences ; Carcinoma, Squamous Cell - etiology ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Female ; Genetic Predisposition to Disease ; Head and Neck Neoplasms - etiology ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - metabolism ; Humans ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - etiology ; Mouth Neoplasms - genetics ; Mouth Neoplasms - metabolism ; Mutation ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Papillomavirus Infections - complications ; Polymorphism, Genetic ; Precancerous Conditions - etiology ; Precancerous Conditions - genetics ; Precancerous Conditions - metabolism ; Review ; Risk Factors ; Smoking - adverse effects ; Survival Analysis ; Taiwan - epidemiology ; Tumors</subject><ispartof>Cancer science, 2008-08, Vol.99 (8), p.1507-1514</ispartof><rights>2008 Japanese Cancer Association</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6523-1169f304a78a406a2110567824a241308d255a5a96e3558a02f4eb564e3ade823</citedby><cites>FETCH-LOGICAL-c6523-1169f304a78a406a2110567824a241308d255a5a96e3558a02f4eb564e3ade823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159516/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159516/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2008.00863.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20599655$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18754860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yin‐Ju</creatorcontrib><creatorcontrib>Chang, Joseph Tung‐Chieh</creatorcontrib><creatorcontrib>Liao, Chun‐Ta</creatorcontrib><creatorcontrib>Wang, Hung‐Ming</creatorcontrib><creatorcontrib>Yen, Tzu‐Chen</creatorcontrib><creatorcontrib>Chiu, Ching‐Chi</creatorcontrib><creatorcontrib>Lu, Ya‐Ching</creatorcontrib><creatorcontrib>Li, Hsiao‐Fang</creatorcontrib><creatorcontrib>Cheng, Ann‐Joy</creatorcontrib><title>Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Head and neck cancer (HNC) is one of the 10 most frequent cancers worldwide, with an estimated over 500 000 new cases being diagnosed annually. The overall 5‐year survival rate in patients with HNC is one of the lowest among common malignant neoplasms and has not significantly changed during the last two decades. Oral cavity squamous cell carcinoma (OSCC) shares part of HNC and has been reported to be increasing in the betel quid chewing area in recent years. During 2006, OSCC has become the sixth most common type of cancer in Taiwan, and it is also the fourth most common type of cancer among men. It follows that this type of cancer wreaks a high social and personal cost. Environmental carcinogens such as betel quid chewing, tobacco smoking and alcohol drinking have been identified as major risk factors for head and neck cancer. There is growing interest in understanding the relationship between genetic susceptibility and the prevalent environmental carcinogens for HNC prevention. Within this review, we discuss the molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area. Knowledge of molecular carcinogenesis of HNC may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics. (Cancer Sci 2008; 99: 1507–1514)</description><subject>Adult</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Areca - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Head and Neck Neoplasms - etiology</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - etiology</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mutation</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Papillomavirus Infections - complications</subject><subject>Polymorphism, Genetic</subject><subject>Precancerous Conditions - etiology</subject><subject>Precancerous Conditions - genetics</subject><subject>Precancerous Conditions - metabolism</subject><subject>Review</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Survival Analysis</subject><subject>Taiwan - epidemiology</subject><subject>Tumors</subject><issn>1347-9032</issn><issn>1349-7006</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhiMEoqXwF5AvcEvwd2yEhKoVUKRKHICzmXUmu16yTmtv-vHvcbqrBU5gyfJI88w743mrijDasHLebBompK1bSnXDKTVNuVo0d4-q02Pi8UPc1pYKflI9y3lDqdDSyqfVCTOtkkbT0-rHBUJHIHYkov9JPESPiYRIdmskS9zhQK6n0BG_xtsQVwQSwluS0GPcEehuZj7P_HYc0E8DpKKRfIjjCiPmkJ9XT3oYMr44vGfV948fvi0u6ssvnz4vzi9rrxUXNWPa9oJKaA1IqoEzRpVuDZfAJRPUdFwpUGA1CqUMUN5LXCotUUCHhouz6v1e92pabrGb50swuKsUtpDu3QjB_Z2JYe1W440r-1RWMV0UXh8U0ng9Yd65bcgehwEijlN22paVMW7_CTJrrBBsBs0e9GnMOWF_HIfRuS9zGzf75Wa_3GykezDS3ZXSl39-53fhwbkCvDoAkD0MfSpOhHzkOFXWaqUK927P3YYB7_97ALc4_1oC8QvrkLiQ</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Chen, Yin‐Ju</creator><creator>Chang, Joseph Tung‐Chieh</creator><creator>Liao, Chun‐Ta</creator><creator>Wang, Hung‐Ming</creator><creator>Yen, Tzu‐Chen</creator><creator>Chiu, Ching‐Chi</creator><creator>Lu, Ya‐Ching</creator><creator>Li, Hsiao‐Fang</creator><creator>Cheng, Ann‐Joy</creator><general>Blackwell Publishing Asia</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200808</creationdate><title>Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis</title><author>Chen, Yin‐Ju ; Chang, Joseph Tung‐Chieh ; Liao, Chun‐Ta ; Wang, Hung‐Ming ; Yen, Tzu‐Chen ; Chiu, Ching‐Chi ; Lu, Ya‐Ching ; Li, Hsiao‐Fang ; Cheng, Ann‐Joy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6523-1169f304a78a406a2110567824a241308d255a5a96e3558a02f4eb564e3ade823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Areca - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - etiology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Head and Neck Neoplasms - etiology</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - etiology</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mutation</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Papillomavirus Infections - complications</topic><topic>Polymorphism, Genetic</topic><topic>Precancerous Conditions - etiology</topic><topic>Precancerous Conditions - genetics</topic><topic>Precancerous Conditions - metabolism</topic><topic>Review</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Survival Analysis</topic><topic>Taiwan - epidemiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yin‐Ju</creatorcontrib><creatorcontrib>Chang, Joseph Tung‐Chieh</creatorcontrib><creatorcontrib>Liao, Chun‐Ta</creatorcontrib><creatorcontrib>Wang, Hung‐Ming</creatorcontrib><creatorcontrib>Yen, Tzu‐Chen</creatorcontrib><creatorcontrib>Chiu, Ching‐Chi</creatorcontrib><creatorcontrib>Lu, Ya‐Ching</creatorcontrib><creatorcontrib>Li, Hsiao‐Fang</creatorcontrib><creatorcontrib>Cheng, Ann‐Joy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chen, Yin‐Ju</au><au>Chang, Joseph Tung‐Chieh</au><au>Liao, Chun‐Ta</au><au>Wang, Hung‐Ming</au><au>Yen, Tzu‐Chen</au><au>Chiu, Ching‐Chi</au><au>Lu, Ya‐Ching</au><au>Li, Hsiao‐Fang</au><au>Cheng, Ann‐Joy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2008-08</date><risdate>2008</risdate><volume>99</volume><issue>8</issue><spage>1507</spage><epage>1514</epage><pages>1507-1514</pages><issn>1347-9032</issn><issn>1349-7006</issn><eissn>1349-7006</eissn><abstract>Head and neck cancer (HNC) is one of the 10 most frequent cancers worldwide, with an estimated over 500 000 new cases being diagnosed annually. The overall 5‐year survival rate in patients with HNC is one of the lowest among common malignant neoplasms and has not significantly changed during the last two decades. Oral cavity squamous cell carcinoma (OSCC) shares part of HNC and has been reported to be increasing in the betel quid chewing area in recent years. During 2006, OSCC has become the sixth most common type of cancer in Taiwan, and it is also the fourth most common type of cancer among men. It follows that this type of cancer wreaks a high social and personal cost. Environmental carcinogens such as betel quid chewing, tobacco smoking and alcohol drinking have been identified as major risk factors for head and neck cancer. There is growing interest in understanding the relationship between genetic susceptibility and the prevalent environmental carcinogens for HNC prevention. Within this review, we discuss the molecular and cellular aspects of HNC carcinogenesis in Taiwan, an endemic betel quid chewing area. Knowledge of molecular carcinogenesis of HNC may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics. (Cancer Sci 2008; 99: 1507–1514)</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>18754860</pmid><doi>10.1111/j.1349-7006.2008.00863.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access |
| subjects | Adult Alcohol Drinking - adverse effects Areca - adverse effects Biological and medical sciences Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Female Genetic Predisposition to Disease Head and Neck Neoplasms - etiology Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Humans Male Medical sciences Middle Aged Mouth Neoplasms - etiology Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mutation Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Papillomavirus Infections - complications Polymorphism, Genetic Precancerous Conditions - etiology Precancerous Conditions - genetics Precancerous Conditions - metabolism Review Risk Factors Smoking - adverse effects Survival Analysis Taiwan - epidemiology Tumors |
| title | Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis |
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