Interferon regulatory factor family of transcription factors and regulation of oncogenesis
A family of transcription factors, the interferon regulatory factors (IRF), was identified originally in the context of the regulation of the type I interferon (IFN)‐α/β system. The IRF family has now expanded to nine members, and gene‐disruption studies have revealed the critical involvement of the...
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| Veröffentlicht in: | Cancer science 2008-03, Vol.99 (3), p.467-478 |
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| container_end_page | 478 |
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| container_title | Cancer science |
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| creator | Takaoka, Akinori Tamura, Tomohiko Taniguchi, Tadatsugu |
| description | A family of transcription factors, the interferon regulatory factors (IRF), was identified originally in the context of the regulation of the type I interferon (IFN)‐α/β system. The IRF family has now expanded to nine members, and gene‐disruption studies have revealed the critical involvement of these members in multiple facets of host defense systems, such as innate and adaptive immune responses and tumor suppression. In the present review article, we aim at summarizing our current knowledge of the roles of IRF in host defense, with special emphasis on their involvement in the regulation of oncogenesis. (Cancer Sci 2008; 99: 467–478) |
| doi_str_mv | 10.1111/j.1349-7006.2007.00720.x |
| format | Article |
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| ispartof | Cancer science, 2008-03, Vol.99 (3), p.467-478 |
| issn | 1347-9032 1349-7006 1349-7006 |
| language | eng |
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| source | Wiley Online Library Open Access |
| subjects | Animals Biological and medical sciences Evolution, Molecular Humans Interferon Regulatory Factors - metabolism Medical sciences Mutation Neoplasms - genetics Neoplasms - metabolism Oncogene Proteins - metabolism Review Signal Transduction Transcription Factors - metabolism Tumors |
| title | Interferon regulatory factor family of transcription factors and regulation of oncogenesis |
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