Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin

Many advanced cancers receive cisplatin‐based chemotherapy. However, cisplatin resistance is a major obstacle for cancer chemotherapy. Foxo3a is a member of the Foxo transcription factor family, which modulates the expression of genes involved in DNA damage repair, apoptosis, and other cellular proc...

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Veröffentlicht in:	Cancer science 2010-05, Vol.101 (5), p.1177-1185
Hauptverfasser:	Shiota, Masaki, Yokomizo, Akira, Kashiwagi, Eiji, Tada, Yasuhiro, Inokuchi, Junichi, Tatsugami, Katsunori, Kuroiwa, Kentaro, Uchiumi, Takeshi, Seki, Narihito, Naito, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Cell Proliferation Cisplatin - pharmacology Drug Resistance, Neoplasm Forkhead Box Protein O3 Forkhead Transcription Factors - analysis Forkhead Transcription Factors - physiology Humans Medical sciences Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Original Plicamycin - pharmacology Reactive Oxygen Species - metabolism Tumors
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