Establishment of an immortalized cell line from a precancerous lesion of lung adenocarcinoma, and genes highly expressed in the early stages of lung adenocarcinoma development

Atypical adenomatous hyperplasia (AAH) is classified as a precancerous lesion of lung adenocarcinoma. We established an immortalized AAH cell line (PL16T) and a human non‐neoplastic bronchial epithelial cell line (PL16B) from the same patient by transfection with the gene for SV40 large T antigen. T...

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Veröffentlicht in:	Cancer science 2005-10, Vol.96 (10), p.668-675
Hauptverfasser:	Shimada, Aki, Kano, Junko, Ishiyama, Tadashi, Okubo, Chigusa, Iijima, Tatsuo, Morishita, Yukio, Minami, Yuko, Inadome, Yukinori, Shu, Yujian, Sugita, Shintaro, Takeuchi, Tomoyo, Noguchi, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Antigens, Neoplasm - analysis Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Adhesion Molecules - analysis Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - genetics Chemotactic Factors - analysis Chemotactic Factors - biosynthesis Chemotactic Factors - genetics Female Gene Expression Profiling Humans Hyperplasia Lung - pathology Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences Middle Aged Neoplasm Staging Nucleic Acid Hybridization Original Pneumology Precancerous Conditions - genetics Precancerous Conditions - pathology S100 Proteins - analysis S100 Proteins - biosynthesis S100 Proteins - genetics Simian virus 40 Tumor Cells, Cultured Tumors Tumors of the respiratory system and mediastinum
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