Engineered therapeutic antibodies with improved effector functions

In the past decade, more than 20 therapeutic antibodies have been approved for clinical use and many others are now at the clinical and preclinical stage of development. Fragment crystallizable (Fc)‐dependent antibody functions, such as antibody‐dependent cell‐mediated cytotoxicity (ADCC), complemen...

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Veröffentlicht in:	Cancer science 2009-09, Vol.100 (9), p.1566-1572
Hauptverfasser:	Kubota, Tsuguo, Niwa, Rinpei, Satoh, Mitsuo, Akinaga, Shiro, Shitara, Kenya, Hanai, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Biological and medical sciences Humans Medical sciences Neoplasms - therapy Protein Engineering Review Tumors
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