Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. To identify potential diagnostic markers for ESCC and therapeutic targets for ESCC, we used Serial Analysis of Gene Expression (SAGE) on one ESCC sample. We obtained a total of 14 430 tags, including 5765 tha...
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| Veröffentlicht in: | Cancer science 2010-04, Vol.101 (4), p.1038-1044 |
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| creator | Sakamoto, Naoya Oue, Naohide Noguchi, Tsuyoshi Sentani, Kazuhiro Anami, Katsuhiro Sanada, Yuichi Yoshida, Kazuhiro Yasui, Wataru |
| description | Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. To identify potential diagnostic markers for ESCC and therapeutic targets for ESCC, we used Serial Analysis of Gene Expression (SAGE) on one ESCC sample. We obtained a total of 14 430 tags, including 5765 that were unique. By comparing SAGE tags from the ESCC sample with those from normal human squamous esophagus, we found several genes that were differentially expressed between ESCC and normal squamous esophagus. Among these, we focused on the ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) gene because quantitative RT‐PCR analysis showed a high level of ADAMTS16 expression in eight out of 20 ESCC samples (40%), but not in 15 kinds of normal tissues. Western blot analysis also showed upregulation of ADAMTS16 protein in ESCC tissues. Furthermore, ADAMTS16 protein was detected in culture media from the TE5 esophageal cancer cell line. Knockdown of ADAMTS16 in TE5 cells inhibited both cell growth and invasion ability. Our present SAGE data provide a list of genes potentially associated with ESCC. ADAMTS16 could be a novel diagnostic and therapeutic target for ESCC.
(Cancer Sci 2010; 101: 1038–1044) |
| doi_str_mv | 10.1111/j.1349-7006.2009.01477.x |
| format | Article |
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(Cancer Sci 2010; 101: 1038–1044)</description><identifier>ISSN: 1347-9032</identifier><identifier>ISSN: 1349-7006</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2009.01477.x</identifier><identifier>PMID: 20128818</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ADAM Proteins - metabolism ; ADAMTS Proteins ; Aged ; Biological and medical sciences ; Biomarkers ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell culture ; Cell growth ; Cell Line, Tumor ; Culture media ; Esophageal cancer ; Esophageal carcinoma ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - pathology ; Esophagus ; Gastric cancer ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression ; Gene Knockdown Techniques ; Humans ; Keratin ; Male ; Malignancy ; Medical sciences ; Metalloproteinase ; Original ; Proteins ; Reverse Transcriptase Polymerase Chain Reaction ; Serial analysis of gene expression ; Squamous cell carcinoma ; Therapeutic applications ; Therapeutic targets ; Thrombospondin ; Tumors ; Up-Regulation</subject><ispartof>Cancer science, 2010-04, Vol.101 (4), p.1038-1044</ispartof><rights>2010 Japanese Cancer Association</rights><rights>2015 INIST-CNRS</rights><rights>Copyright John Wiley & Sons, Inc. Apr 2010</rights><rights>Copyright John Wiley & Sons, Inc. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6797-a13d6357d3c2a687bdbb458beb3ae39bec59505dd07686990807d82ba2af24bb3</citedby><cites>FETCH-LOGICAL-c6797-a13d6357d3c2a687bdbb458beb3ae39bec59505dd07686990807d82ba2af24bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159120/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159120/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,1418,11566,27928,27929,45578,45579,46056,46480,53795,53797</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2009.01477.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22963654$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20128818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakamoto, Naoya</creatorcontrib><creatorcontrib>Oue, Naohide</creatorcontrib><creatorcontrib>Noguchi, Tsuyoshi</creatorcontrib><creatorcontrib>Sentani, Kazuhiro</creatorcontrib><creatorcontrib>Anami, Katsuhiro</creatorcontrib><creatorcontrib>Sanada, Yuichi</creatorcontrib><creatorcontrib>Yoshida, Kazuhiro</creatorcontrib><creatorcontrib>Yasui, Wataru</creatorcontrib><title>Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. To identify potential diagnostic markers for ESCC and therapeutic targets for ESCC, we used Serial Analysis of Gene Expression (SAGE) on one ESCC sample. We obtained a total of 14 430 tags, including 5765 that were unique. By comparing SAGE tags from the ESCC sample with those from normal human squamous esophagus, we found several genes that were differentially expressed between ESCC and normal squamous esophagus. Among these, we focused on the ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) gene because quantitative RT‐PCR analysis showed a high level of ADAMTS16 expression in eight out of 20 ESCC samples (40%), but not in 15 kinds of normal tissues. Western blot analysis also showed upregulation of ADAMTS16 protein in ESCC tissues. Furthermore, ADAMTS16 protein was detected in culture media from the TE5 esophageal cancer cell line. Knockdown of ADAMTS16 in TE5 cells inhibited both cell growth and invasion ability. Our present SAGE data provide a list of genes potentially associated with ESCC. ADAMTS16 could be a novel diagnostic and therapeutic target for ESCC.
(Cancer Sci 2010; 101: 1038–1044)</description><subject>ADAM Proteins - metabolism</subject><subject>ADAMTS Proteins</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell culture</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Culture media</subject><subject>Esophageal cancer</subject><subject>Esophageal carcinoma</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagus</subject><subject>Gastric cancer</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression</subject><subject>Gene Knockdown Techniques</subject><subject>Humans</subject><subject>Keratin</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical sciences</subject><subject>Metalloproteinase</subject><subject>Original</subject><subject>Proteins</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Serial analysis of gene expression</subject><subject>Squamous cell carcinoma</subject><subject>Therapeutic applications</subject><subject>Therapeutic targets</subject><subject>Thrombospondin</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>1347-9032</issn><issn>1349-7006</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNktmO0zAUhiMEYoaBV0CWEOIqwUviBQmhqqzSIC46XFvHjtNxlcYdu4H2CXhtnGkpywUa39jy-c6v_yxFgQiuSD4vVxVhtSoFxryiGKsKk1qIanevOD8F7t--Rakwo2fFo5RWGDNeq_phcUYxoVISeV78WLjooUcwQL9PPqHQoaUbHHK7TXQp-TBMXy6FzTUsXSbTzQjrMCZkXd8jC9H6IazhFZq9nX2-WhCOssqYk5djD1vXIj_cIf1x8aCDPrknx_ui-Pr-3dX8Y3n55cOn-eyytFwoUQJhLWeNaJmlwKUwrTF1I40zDBxTxtlGNbhpWyy45EphiUUrqQEKHa2NYRfFm4PuZjRr11o3bCP0ehP9GuJeB_D678jgr_UyfNO57Y0iFGeFF0eFGG5Gl7Z67dNUDAwu16VFLVUtKOeZfPYPuQpjzI1OmhFKhMJCyf9RVHLSCJn1MiUPlI0hpei6k2WCJ29Er_Q0ej2NXk87oW93Qu9y6tM_Sz4l_lqCDDw_ApAs9F2Ewfr0m6OKM95MHl4fuO--d_s7G9Dz2WJ6sZ9qaNO_</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Sakamoto, Naoya</creator><creator>Oue, Naohide</creator><creator>Noguchi, Tsuyoshi</creator><creator>Sentani, Kazuhiro</creator><creator>Anami, Katsuhiro</creator><creator>Sanada, Yuichi</creator><creator>Yoshida, Kazuhiro</creator><creator>Yasui, Wataru</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>John Wiley & Sons, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201004</creationdate><title>Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma</title><author>Sakamoto, Naoya ; Oue, Naohide ; Noguchi, Tsuyoshi ; Sentani, Kazuhiro ; Anami, Katsuhiro ; Sanada, Yuichi ; Yoshida, Kazuhiro ; Yasui, Wataru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6797-a13d6357d3c2a687bdbb458beb3ae39bec59505dd07686990807d82ba2af24bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>ADAM Proteins - metabolism</topic><topic>ADAMTS Proteins</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell culture</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Culture media</topic><topic>Esophageal cancer</topic><topic>Esophageal carcinoma</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagus</topic><topic>Gastric cancer</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression</topic><topic>Gene Knockdown Techniques</topic><topic>Humans</topic><topic>Keratin</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical sciences</topic><topic>Metalloproteinase</topic><topic>Original</topic><topic>Proteins</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Serial analysis of gene expression</topic><topic>Squamous cell carcinoma</topic><topic>Therapeutic applications</topic><topic>Therapeutic targets</topic><topic>Thrombospondin</topic><topic>Tumors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakamoto, Naoya</creatorcontrib><creatorcontrib>Oue, Naohide</creatorcontrib><creatorcontrib>Noguchi, Tsuyoshi</creatorcontrib><creatorcontrib>Sentani, Kazuhiro</creatorcontrib><creatorcontrib>Anami, Katsuhiro</creatorcontrib><creatorcontrib>Sanada, Yuichi</creatorcontrib><creatorcontrib>Yoshida, Kazuhiro</creatorcontrib><creatorcontrib>Yasui, Wataru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Sakamoto, Naoya</au><au>Oue, Naohide</au><au>Noguchi, Tsuyoshi</au><au>Sentani, Kazuhiro</au><au>Anami, Katsuhiro</au><au>Sanada, Yuichi</au><au>Yoshida, Kazuhiro</au><au>Yasui, Wataru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2010-04</date><risdate>2010</risdate><volume>101</volume><issue>4</issue><spage>1038</spage><epage>1044</epage><pages>1038-1044</pages><issn>1347-9032</issn><issn>1349-7006</issn><eissn>1349-7006</eissn><abstract>Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. To identify potential diagnostic markers for ESCC and therapeutic targets for ESCC, we used Serial Analysis of Gene Expression (SAGE) on one ESCC sample. We obtained a total of 14 430 tags, including 5765 that were unique. By comparing SAGE tags from the ESCC sample with those from normal human squamous esophagus, we found several genes that were differentially expressed between ESCC and normal squamous esophagus. Among these, we focused on the ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) gene because quantitative RT‐PCR analysis showed a high level of ADAMTS16 expression in eight out of 20 ESCC samples (40%), but not in 15 kinds of normal tissues. Western blot analysis also showed upregulation of ADAMTS16 protein in ESCC tissues. Furthermore, ADAMTS16 protein was detected in culture media from the TE5 esophageal cancer cell line. Knockdown of ADAMTS16 in TE5 cells inhibited both cell growth and invasion ability. Our present SAGE data provide a list of genes potentially associated with ESCC. ADAMTS16 could be a novel diagnostic and therapeutic target for ESCC.
(Cancer Sci 2010; 101: 1038–1044)</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20128818</pmid><doi>10.1111/j.1349-7006.2009.01477.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ADAM Proteins - metabolism ADAMTS Proteins Aged Biological and medical sciences Biomarkers Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell culture Cell growth Cell Line, Tumor Culture media Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Gene Knockdown Techniques Humans Keratin Male Malignancy Medical sciences Metalloproteinase Original Proteins Reverse Transcriptase Polymerase Chain Reaction Serial analysis of gene expression Squamous cell carcinoma Therapeutic applications Therapeutic targets Thrombospondin Tumors Up-Regulation |
| title | Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma |
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