Glutathione S‐transferase M1 inhibits dexamethasone‐induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line

(Cancer Sci 2010; 101: 767–773) Glutathione S‐transferase μ (GSTM1) is mainly known as a detoxification enzyme but it has also been shown to be a negative regulator of apoptosis‐related signaling cascades. Recently GSTM1 has been reported to be a significant risk factor for hematological relapse in...

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Veröffentlicht in:	Cancer science 2010-03, Vol.101 (3), p.767-773
Hauptverfasser:	Hosono, Naoko, Kishi, Shinji, Iho, Sumiko, Urasaki, Yoshimasa, Yoshida, Akira, Kurooka, Hisanori, Yokota, Yoshifumi, Ueda, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis Regulatory Proteins - antagonists & inhibitors Bcl-2-Like Protein 11 Biological and medical sciences Buthionine Sulfoximine - pharmacology Cell Line, Tumor Dexamethasone - pharmacology Drug Resistance, Neoplasm Glutathione Transferase - physiology Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Membrane Proteins - antagonists & inhibitors NF-kappa B p50 Subunit - physiology Original p38 Mitogen-Activated Protein Kinases - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Proto-Oncogene Proteins - antagonists & inhibitors Tumors
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