In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate

To clarify the role of 8‐OHdG formation as a starting point for carcinogenesis, we examined the dose‐dependence and time‐course of changes of OGG1 mRNA expression, 8‐OHdG levels and in vivo mutations in the kidneys of gpt delta rats given KBrO3 in their drinking water for 13 weeks. There were no rem...

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Veröffentlicht in:	Cancer science 2006-09, Vol.97 (9), p.829-835
Hauptverfasser:	Umemura, Takashi, Kanki, Keita, Kuroiwa, Yuichi, Ishii, Yuji, Okano, Keita, Nohmi, Takehiko, Nishikawa, Akiyoshi, Hirose, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2'-Deoxyguanosine Animal tumors. Experimental tumors Animals Animals, Genetically Modified Biological and medical sciences Bromates - toxicity Carcinogens - toxicity Cell Transformation, Neoplastic - drug effects Cell Transformation, Neoplastic - metabolism Deoxyguanosine - analogs & derivatives Deoxyguanosine - biosynthesis DNA Damage - drug effects DNA Glycosylases - biosynthesis DNA Glycosylases - drug effects Dose-Response Relationship, Drug Experimental renal and urinary tract tumors Kidney - drug effects Kidney - pathology Kidney Neoplasms - chemically induced Kidney Neoplasms - genetics Kidney Neoplasms - pathology Male Medical sciences Mutation Nitrilotriacetic Acid - toxicity Original Oxidative Stress - drug effects Precancerous Conditions - chemically induced Precancerous Conditions - genetics Precancerous Conditions - pathology Rats Rats, Inbred F344 Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Time Factors Tumors
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