XAF1 as a prognostic biomarker and therapeutic target in pancreatic cancer

XAF1 (X chromosome‐linked inhibitor of apoptosis [XIAP]‐associated factor 1) is a novel XIAP modulator that negatively regulates the anti‐apoptotic effects of XIAP and sensitizes cells to other cell death triggers. It has been reported to be downregulated in a variety of human cancer cell lines. How...

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Veröffentlicht in:	Cancer science 2010-02, Vol.101 (2), p.559-567
Hauptverfasser:	Huang, Jia, Yao, Wei‐yan, Zhu, Qi, Tu, Shui‐ping, Yuan, Fei, Wang, Hua‐feng, Zhang, Yong‐ping, Yuan, Yao‐zong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Aged Animals Apoptosis Apoptosis Regulatory Proteins Biological and medical sciences Biomarkers, Tumor - analysis Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mice Middle Aged Neoplasm Proteins - analysis Neoplasm Proteins - physiology Original Pancreatic Neoplasms - chemistry Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Prognosis Proportional Hazards Models Tumors X-Linked Inhibitor of Apoptosis Protein - analysis Xenograft Model Antitumor Assays
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