Matriptase activates stromelysin (MMP‐3) and promotes tumor growth and angiogenesis

Matriptase/MT‐SP1, a type II membrane serine protease widely expressed in normal epithelial cells and human carcinoma cells, is thought to be involved in cancer progression. To clarify this possibility, we overexpressed exogenous matriptase in the human stomach cancer cell line AZ521. In vitro, the...

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Veröffentlicht in:	Cancer science 2006-12, Vol.97 (12), p.1327-1334
Hauptverfasser:	Jin, Xinlian, Yagi, Motoki, Akiyama, Nagisa, Hirosaki, Tomomi, Higashi, Shouichi, Lin, Chen‐Yong, Dickson, Robert B., Kitamura, Hitoshi, Miyazaki, Kaoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Enzyme Activation Gene Expression Regulation, Neoplastic General aspects Humans Immunoblotting Immunoenzyme Techniques Male Matrix Metalloproteinase 3 - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Original Reverse Transcriptase Polymerase Chain Reaction Serine Endopeptidases - pharmacology Stomach Neoplasms - blood supply Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - enzymology Tumors Up-Regulation
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