APC promoter hypermethylation is an early event in endometrial tumorigenesis

The aim of the current study was to investigate the role of promoter methylation of adenomatous polyposis coli (APC) and epithelial cadherin (E‐cadherin) genes in endometrial tumorigenesis. The methylation status of both genes was investigated in 43 cases of normal endometrium, 21 simple hyperplasia...

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Veröffentlicht in:	Cancer science 2010-02, Vol.101 (2), p.321-327
Hauptverfasser:	Ignatov, Atanas, Bischoff, Joachim, Ignatov, Tanja, Schwarzenau, Christa, Krebs, Thomas, Kuester, Doerthe, Costa, Serban D., Roessner, Albert, Semczuk, Andrzej, Schneider‐Stock, Regine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Cadherins - genetics DNA Methylation Endometrial Neoplasms - etiology Endometrial Neoplasms - genetics Endometrial Neoplasms - pathology Female Female genital diseases Genes, APC Gynecology. Andrology. Obstetrics Humans Ki-67 Antigen - analysis Medical sciences Middle Aged Original Promoter Regions, Genetic Tumors
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