Susceptibility of Snark‐deficient mice to azoxymethane‐induced colorectal tumorigenesis and the formation of aberrant crypt foci
SNF‐1/5′‐AMP‐activated kinase (AMPK)‐related kinase (SNARK) is a member of the AMPK‐related kinases. Snark+/– mice exhibited mature‐onset obesity and related metabolic disorders. Obesity is regarded as a risk factor for colorectal cancer. To investigate whether Snark deficiency is involved in tumori...
Gespeichert in:
| Veröffentlicht in: | Cancer science 2008-04, Vol.99 (4), p.677-682 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 682 |
|---|---|
| container_issue | 4 |
| container_start_page | 677 |
| container_title | Cancer science |
| container_volume | 99 |
| creator | Tsuchihara, Katsuya Ogura, Tsutomu Fujioka, Rumi Fujii, Satoshi Kuga, Wataru Saito, Marie Ochiya, Takahiro Ochiai, Atsushi Esumi, Hiroyasu |
| description | SNF‐1/5′‐AMP‐activated kinase (AMPK)‐related kinase (SNARK) is a member of the AMPK‐related kinases. Snark+/– mice exhibited mature‐onset obesity and related metabolic disorders. Obesity is regarded as a risk factor for colorectal cancer. To investigate whether Snark deficiency is involved in tumorigenesis in the large intestine, obese Snark+/– mice were treated with a chemical carcinogen, azoxymethane (AOM). The incidences of both adenomas and aberrant crypt foci (ACF) were significantly higher in Snark+/– mice than in their wild‐type counterparts 28 weeks after the completion of AOM treatment (10 mg/kg/week for 8 weeks). Furthermore, ACF formation was enhanced in Snark+/– mice treated with AOM for 2 weeks, suggesting that Snark deficiency contributed to the early phase of tumorigenesis. The total number of ACF was correlated with bodyweight in Snark+/– and Snark+/+ mice, suggesting that obesity was a risk factor for colorectal tumorigenesis in this model. However, the correlation coefficient was higher in Snark+/– mice. Moreover, AOM‐induced ACF formation was also enhanced in preobese Snark+/– mice. Together, these findings suggest that AOM‐induced tumorigenesis in Snark+/– mice was enhanced via obesity‐dependent and ‐independent mechanisms. (Cancer Sci 2008; 99: 677–682) |
| doi_str_mv | 10.1111/j.1349-7006.2008.00734.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11158890</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70451736</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5714-17105a050b6085a9ca6a9be47e510a2f44ea6e81a8452b6204dd1d7a30e85db53</originalsourceid><addsrcrecordid>eNqNkc-O0zAQxiMEYpfCKyBf4JZix3acSEhoVfFPWolD4WxNnMnWJYmL7SwtJw48AM_Ik-BsqwI3fLGl-c3nme_LMsLokqXzYrtkXNS5orRcFpRWS0oVF8v9vezyXLh_91Z5TXlxkT0KYUspL0UtHmYXrOJUSc4vsx_rKRjcRdvY3sYDcR1Zj-A___r-s8XOGotjJIM1SKIj8M3tDwPGDYyYADu2k8GWGNc7jyZCT-I0OG9vcMRgA4GxJXGDpHN-gGjdOMtDg95DUjX-sIupZuzj7EEHfcAnp3uRfXrz-uPqXX794e371dV1bqRiImeKUQlU0qaklYTaQAl1g0KhZBSKTgiEEisGlZBFUxZUtC1rFXCKlWwbyRfZq6PubmoGbE3azUOvd94O4A_agdX_Vka70TfuVifPZVUlJxfZ85OCd18mDFEPNvnX98kRNwWtqJBM8TKB1RE03oXgsTv_wugsx_RWz1HpOSo9Z6jvMtT71Pr07yn_NJ5CS8CzEwDBQN8lN40NZ66ghWJKzeu-PHJfbY-H_x5Ar67W6cF_A_mLvXs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70451736</pqid></control><display><type>article</type><title>Susceptibility of Snark‐deficient mice to azoxymethane‐induced colorectal tumorigenesis and the formation of aberrant crypt foci</title><source>Wiley Online Library Open Access</source><creator>Tsuchihara, Katsuya ; Ogura, Tsutomu ; Fujioka, Rumi ; Fujii, Satoshi ; Kuga, Wataru ; Saito, Marie ; Ochiya, Takahiro ; Ochiai, Atsushi ; Esumi, Hiroyasu</creator><creatorcontrib>Tsuchihara, Katsuya ; Ogura, Tsutomu ; Fujioka, Rumi ; Fujii, Satoshi ; Kuga, Wataru ; Saito, Marie ; Ochiya, Takahiro ; Ochiai, Atsushi ; Esumi, Hiroyasu</creatorcontrib><description>SNF‐1/5′‐AMP‐activated kinase (AMPK)‐related kinase (SNARK) is a member of the AMPK‐related kinases. Snark+/– mice exhibited mature‐onset obesity and related metabolic disorders. Obesity is regarded as a risk factor for colorectal cancer. To investigate whether Snark deficiency is involved in tumorigenesis in the large intestine, obese Snark+/– mice were treated with a chemical carcinogen, azoxymethane (AOM). The incidences of both adenomas and aberrant crypt foci (ACF) were significantly higher in Snark+/– mice than in their wild‐type counterparts 28 weeks after the completion of AOM treatment (10 mg/kg/week for 8 weeks). Furthermore, ACF formation was enhanced in Snark+/– mice treated with AOM for 2 weeks, suggesting that Snark deficiency contributed to the early phase of tumorigenesis. The total number of ACF was correlated with bodyweight in Snark+/– and Snark+/+ mice, suggesting that obesity was a risk factor for colorectal tumorigenesis in this model. However, the correlation coefficient was higher in Snark+/– mice. Moreover, AOM‐induced ACF formation was also enhanced in preobese Snark+/– mice. Together, these findings suggest that AOM‐induced tumorigenesis in Snark+/– mice was enhanced via obesity‐dependent and ‐independent mechanisms. (Cancer Sci 2008; 99: 677–682)</description><identifier>ISSN: 1347-9032</identifier><identifier>ISSN: 1349-7006</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2008.00734.x</identifier><identifier>PMID: 18307533</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Animals ; Azoxymethane - toxicity ; Biological and medical sciences ; Body Weight ; Carcinogens - toxicity ; Colorectal Neoplasms - chemically induced ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Tract - enzymology ; Gastrointestinal Tract - pathology ; Genetic Predisposition to Disease ; Medical sciences ; Mice ; Mice, Mutant Strains ; Obesity - complications ; Obesity - genetics ; Original ; Precancerous Conditions - chemically induced ; Precancerous Conditions - genetics ; Precancerous Conditions - pathology ; Protein Serine-Threonine Kinases - genetics ; Risk Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Cancer science, 2008-04, Vol.99 (4), p.677-682</ispartof><rights>2008 Japanese Cancer Association</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5714-17105a050b6085a9ca6a9be47e510a2f44ea6e81a8452b6204dd1d7a30e85db53</citedby><cites>FETCH-LOGICAL-c5714-17105a050b6085a9ca6a9be47e510a2f44ea6e81a8452b6204dd1d7a30e85db53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11158890/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11158890/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2008.00734.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20271775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18307533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuchihara, Katsuya</creatorcontrib><creatorcontrib>Ogura, Tsutomu</creatorcontrib><creatorcontrib>Fujioka, Rumi</creatorcontrib><creatorcontrib>Fujii, Satoshi</creatorcontrib><creatorcontrib>Kuga, Wataru</creatorcontrib><creatorcontrib>Saito, Marie</creatorcontrib><creatorcontrib>Ochiya, Takahiro</creatorcontrib><creatorcontrib>Ochiai, Atsushi</creatorcontrib><creatorcontrib>Esumi, Hiroyasu</creatorcontrib><title>Susceptibility of Snark‐deficient mice to azoxymethane‐induced colorectal tumorigenesis and the formation of aberrant crypt foci</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>SNF‐1/5′‐AMP‐activated kinase (AMPK)‐related kinase (SNARK) is a member of the AMPK‐related kinases. Snark+/– mice exhibited mature‐onset obesity and related metabolic disorders. Obesity is regarded as a risk factor for colorectal cancer. To investigate whether Snark deficiency is involved in tumorigenesis in the large intestine, obese Snark+/– mice were treated with a chemical carcinogen, azoxymethane (AOM). The incidences of both adenomas and aberrant crypt foci (ACF) were significantly higher in Snark+/– mice than in their wild‐type counterparts 28 weeks after the completion of AOM treatment (10 mg/kg/week for 8 weeks). Furthermore, ACF formation was enhanced in Snark+/– mice treated with AOM for 2 weeks, suggesting that Snark deficiency contributed to the early phase of tumorigenesis. The total number of ACF was correlated with bodyweight in Snark+/– and Snark+/+ mice, suggesting that obesity was a risk factor for colorectal tumorigenesis in this model. However, the correlation coefficient was higher in Snark+/– mice. Moreover, AOM‐induced ACF formation was also enhanced in preobese Snark+/– mice. Together, these findings suggest that AOM‐induced tumorigenesis in Snark+/– mice was enhanced via obesity‐dependent and ‐independent mechanisms. (Cancer Sci 2008; 99: 677–682)</description><subject>Animals</subject><subject>Azoxymethane - toxicity</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Carcinogens - toxicity</subject><subject>Colorectal Neoplasms - chemically induced</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal Tract - enzymology</subject><subject>Gastrointestinal Tract - pathology</subject><subject>Genetic Predisposition to Disease</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Obesity - complications</subject><subject>Obesity - genetics</subject><subject>Original</subject><subject>Precancerous Conditions - chemically induced</subject><subject>Precancerous Conditions - genetics</subject><subject>Precancerous Conditions - pathology</subject><subject>Protein Serine-Threonine Kinases - genetics</subject><subject>Risk Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>1347-9032</issn><issn>1349-7006</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-O0zAQxiMEYpfCKyBf4JZix3acSEhoVfFPWolD4WxNnMnWJYmL7SwtJw48AM_Ik-BsqwI3fLGl-c3nme_LMsLokqXzYrtkXNS5orRcFpRWS0oVF8v9vezyXLh_91Z5TXlxkT0KYUspL0UtHmYXrOJUSc4vsx_rKRjcRdvY3sYDcR1Zj-A___r-s8XOGotjJIM1SKIj8M3tDwPGDYyYADu2k8GWGNc7jyZCT-I0OG9vcMRgA4GxJXGDpHN-gGjdOMtDg95DUjX-sIupZuzj7EEHfcAnp3uRfXrz-uPqXX794e371dV1bqRiImeKUQlU0qaklYTaQAl1g0KhZBSKTgiEEisGlZBFUxZUtC1rFXCKlWwbyRfZq6PubmoGbE3azUOvd94O4A_agdX_Vka70TfuVifPZVUlJxfZ85OCd18mDFEPNvnX98kRNwWtqJBM8TKB1RE03oXgsTv_wugsx_RWz1HpOSo9Z6jvMtT71Pr07yn_NJ5CS8CzEwDBQN8lN40NZ66ghWJKzeu-PHJfbY-H_x5Ar67W6cF_A_mLvXs</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Tsuchihara, Katsuya</creator><creator>Ogura, Tsutomu</creator><creator>Fujioka, Rumi</creator><creator>Fujii, Satoshi</creator><creator>Kuga, Wataru</creator><creator>Saito, Marie</creator><creator>Ochiya, Takahiro</creator><creator>Ochiai, Atsushi</creator><creator>Esumi, Hiroyasu</creator><general>Blackwell Publishing Asia</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200804</creationdate><title>Susceptibility of Snark‐deficient mice to azoxymethane‐induced colorectal tumorigenesis and the formation of aberrant crypt foci</title><author>Tsuchihara, Katsuya ; Ogura, Tsutomu ; Fujioka, Rumi ; Fujii, Satoshi ; Kuga, Wataru ; Saito, Marie ; Ochiya, Takahiro ; Ochiai, Atsushi ; Esumi, Hiroyasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5714-17105a050b6085a9ca6a9be47e510a2f44ea6e81a8452b6204dd1d7a30e85db53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Azoxymethane - toxicity</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Carcinogens - toxicity</topic><topic>Colorectal Neoplasms - chemically induced</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal Tract - enzymology</topic><topic>Gastrointestinal Tract - pathology</topic><topic>Genetic Predisposition to Disease</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Obesity - complications</topic><topic>Obesity - genetics</topic><topic>Original</topic><topic>Precancerous Conditions - chemically induced</topic><topic>Precancerous Conditions - genetics</topic><topic>Precancerous Conditions - pathology</topic><topic>Protein Serine-Threonine Kinases - genetics</topic><topic>Risk Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuchihara, Katsuya</creatorcontrib><creatorcontrib>Ogura, Tsutomu</creatorcontrib><creatorcontrib>Fujioka, Rumi</creatorcontrib><creatorcontrib>Fujii, Satoshi</creatorcontrib><creatorcontrib>Kuga, Wataru</creatorcontrib><creatorcontrib>Saito, Marie</creatorcontrib><creatorcontrib>Ochiya, Takahiro</creatorcontrib><creatorcontrib>Ochiai, Atsushi</creatorcontrib><creatorcontrib>Esumi, Hiroyasu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Tsuchihara, Katsuya</au><au>Ogura, Tsutomu</au><au>Fujioka, Rumi</au><au>Fujii, Satoshi</au><au>Kuga, Wataru</au><au>Saito, Marie</au><au>Ochiya, Takahiro</au><au>Ochiai, Atsushi</au><au>Esumi, Hiroyasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibility of Snark‐deficient mice to azoxymethane‐induced colorectal tumorigenesis and the formation of aberrant crypt foci</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2008-04</date><risdate>2008</risdate><volume>99</volume><issue>4</issue><spage>677</spage><epage>682</epage><pages>677-682</pages><issn>1347-9032</issn><issn>1349-7006</issn><eissn>1349-7006</eissn><abstract>SNF‐1/5′‐AMP‐activated kinase (AMPK)‐related kinase (SNARK) is a member of the AMPK‐related kinases. Snark+/– mice exhibited mature‐onset obesity and related metabolic disorders. Obesity is regarded as a risk factor for colorectal cancer. To investigate whether Snark deficiency is involved in tumorigenesis in the large intestine, obese Snark+/– mice were treated with a chemical carcinogen, azoxymethane (AOM). The incidences of both adenomas and aberrant crypt foci (ACF) were significantly higher in Snark+/– mice than in their wild‐type counterparts 28 weeks after the completion of AOM treatment (10 mg/kg/week for 8 weeks). Furthermore, ACF formation was enhanced in Snark+/– mice treated with AOM for 2 weeks, suggesting that Snark deficiency contributed to the early phase of tumorigenesis. The total number of ACF was correlated with bodyweight in Snark+/– and Snark+/+ mice, suggesting that obesity was a risk factor for colorectal tumorigenesis in this model. However, the correlation coefficient was higher in Snark+/– mice. Moreover, AOM‐induced ACF formation was also enhanced in preobese Snark+/– mice. Together, these findings suggest that AOM‐induced tumorigenesis in Snark+/– mice was enhanced via obesity‐dependent and ‐independent mechanisms. (Cancer Sci 2008; 99: 677–682)</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>18307533</pmid><doi>10.1111/j.1349-7006.2008.00734.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1347-9032 |
| ispartof | Cancer science, 2008-04, Vol.99 (4), p.677-682 |
| issn | 1347-9032 1349-7006 1349-7006 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11158890 |
| source | Wiley Online Library Open Access |
| subjects | Animals Azoxymethane - toxicity Biological and medical sciences Body Weight Carcinogens - toxicity Colorectal Neoplasms - chemically induced Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Tract - enzymology Gastrointestinal Tract - pathology Genetic Predisposition to Disease Medical sciences Mice Mice, Mutant Strains Obesity - complications Obesity - genetics Original Precancerous Conditions - chemically induced Precancerous Conditions - genetics Precancerous Conditions - pathology Protein Serine-Threonine Kinases - genetics Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Susceptibility of Snark‐deficient mice to azoxymethane‐induced colorectal tumorigenesis and the formation of aberrant crypt foci |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A05%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Susceptibility%20of%20Snark%E2%80%90deficient%20mice%20to%20azoxymethane%E2%80%90induced%20colorectal%20tumorigenesis%20and%20the%20formation%20of%20aberrant%20crypt%20foci&rft.jtitle=Cancer%20science&rft.au=Tsuchihara,%20Katsuya&rft.date=2008-04&rft.volume=99&rft.issue=4&rft.spage=677&rft.epage=682&rft.pages=677-682&rft.issn=1347-9032&rft.eissn=1349-7006&rft_id=info:doi/10.1111/j.1349-7006.2008.00734.x&rft_dat=%3Cproquest_24P%3E70451736%3C/proquest_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70451736&rft_id=info:pmid/18307533&rfr_iscdi=true |