Re‐evaluation and functional classification of non‐synonymous single nucleotide polymorphisms of the human ATP‐binding cassette transporter ABCG2

Impacts of genetic polymorphisms of the ATP‐binding cassette (ABC) transporter BCRP/MXR1/ABCP (ABCG2) on drug response have been implicated; however, the hitherto reported data involve some inconsistencies. To re‐evaluate the effect of single nucleotide polymorphisms (SNP) of ABCG2 in vitro, we crea...

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Veröffentlicht in:	Cancer science 2007-02, Vol.98 (2), p.231-239
Hauptverfasser:	Tamura, Ai, Wakabayashi, Kanako, Onishi, Yuko, Takeda, Misako, Ikegami, Yoji, Sawada, Seigo, Tsuji, Masahisa, Matsuda, Yoichi, Ishikawa, Toshihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters - classification ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Camptothecin - chemistry Camptothecin - pharmacology Cell Line Chromosomes, Human - genetics DNA, Complementary - genetics Drug Resistance Gene Expression - drug effects Genome, Human - genetics Glutamine - genetics Glutamine - metabolism Humans In Situ Hybridization, Fluorescence Medical sciences Molecular Structure Mutation - genetics Neoplasm Proteins - classification Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Original Polymorphism, Single Nucleotide - genetics Tumors Valine - genetics Valine - metabolism
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