Leukemia‐related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis

TEL/ETV6 located at chromosome 12p13 encodes a member of the E26 transformation‐specific family of transcription factors. TEL is known to be rearranged in a variety of leukemias and solid tumors resulting in the formation of oncogenic chimeric protein. Tel is essential for maintaining hematopoietic...

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Veröffentlicht in:	Cancer science 2009-04, Vol.100 (4), p.689-697
Hauptverfasser:	Eguchi‐Ishimae, Minenori, Eguchi, Mariko, Maki, Kazuhiro, Porcher, Catherine, Shimizu, Ritsuko, Yamamoto, Masayuki, Mitani, Kinuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Erythroid Precursor Cells - cytology Erythroid Precursor Cells - metabolism Erythropoiesis - genetics ETS Translocation Variant 6 Protein GATA1 Transcription Factor - genetics Hematologic and hematopoietic diseases Hemoglobins - biosynthesis Humans Leukemia - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mice Mice, Transgenic Original Promoter Regions, Genetic Proto-Oncogene Proteins c-ets - genetics Repressor Proteins - genetics Tumors
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