DNA intrastrand cross‐link at the 5′‐GA‐3′ sequence formed by busulfan and its role in the cytotoxic effect

Busulfan (1,4‐butanediol dimethanesulfonate) has been used widely for the treatment of patients with chronic myelogenous leukemia. Busulfan is bifunctional and thus may effectively induce DNA damage, which may play an important role in the cytotoxicity. In this study, we compared the cytotoxicity of...

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Veröffentlicht in:	Cancer science 2004-05, Vol.95 (5), p.454-458
Hauptverfasser:	Iwamoto, Takuya, Hiraku, Yusuke, Oikawa, Shinji, Mizutani, Hideki, Kojima, Michio, Kawanishi, Shosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Antineoplastic Agents, Alkylating - pharmacology Biological and medical sciences Busulfan Busulfan - pharmacology Chronic myeloid leukemia Cross-Linking Reagents - pharmacology Cytotoxicity Deoxyribonucleic acid DNA DNA Adducts DNA Damage DNA glycosylase DNA sequencing Dose-Response Relationship, Drug Ethyl methanesulfonate Ethyl Methanesulfonate - pharmacology Genes, p16 Humans Leukemia Leukemia, Promyelocytic, Acute Mass spectroscopy Medical sciences Myeloid leukemia Nucleotide sequence Piperidine Promyeloid leukemia Tumor Cells, Cultured Tumor suppressor genes Tumors
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