DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL‐mediated apoptosis via up‐regulation of TRAIL‐R2/DR5 and caspase‐8

DNA methylation plays a critical role in chromatin remodeling and gene expression. DNA methyltransferases (DNMTs) are hypothesized to mediate cellular DNA methylation status and gene expression during mammalian development and in malignant diseases. In this study, we examined the role of DNA methylt...

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Veröffentlicht in:	Cancer science 2010-06, Vol.101 (6), p.1431-1439
Hauptverfasser:	Kurita, Satoshi, Higuchi, Hajime, Saito, Yoshimasa, Nakamoto, Nobuhiro, Takaishi, Hiromasa, Tada, Shinichiro, Saito, Hidetsugu, Gores, Gregory J., Hibi, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Caspase 8 - genetics Cell Line, Tumor DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - physiology DNA Methylation DNA Methyltransferase 3B Drug Resistance, Neoplasm Gastroenterology. Liver. Pancreas. Abdomen Gene Silencing Humans Liver Neoplasms - drug therapy Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mitochondrial Proteins - metabolism Original Promoter Regions, Genetic Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - physiology RNA, Small Interfering - genetics TNF-Related Apoptosis-Inducing Ligand - pharmacology Tumors Up-Regulation
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