Simultaneous suppression of MITF and BRAFV600E enhanced inhibition of melanoma cell proliferation

Microphthalmia‐associated transcription factor (MITF) is a master gene regulating differentiation of melanocytes, and a lineage survival oncogene mediating pro‐proliferative function in malignant melanoma. However, high expression of MITF also has an anti‐proliferative effect. To clarify the therape...

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Veröffentlicht in:	Cancer science 2009-10, Vol.100 (10), p.1863-1869
Hauptverfasser:	Kido, Kenji, Sumimoto, Hidetoshi, Asada, Sakiyo, Okada, Starlyn M., Yaguchi, Tomonori, Kawamura, Naoshi, Miyagishi, Makoto, Saida, Toshiaki, Kawakami, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Dermatology Medical sciences Original Tumors Tumors of the skin and soft tissue. Premalignant lesions
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