BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer
Transcriptional inactivation of breast cancer gene 1 (BRCA1) by DNA methylation is a frequent event in sporadic breast cancers. To investigate whether BRCA1 methylation is associated with survival in Chinese patients with sporadic breast cancer, BRCA1 methylation was determined using methylation spe...
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| Veröffentlicht in: | Cancer science 2009-09, Vol.100 (9), p.1663-1667 |
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| creator | Chen, Yanglin Zhou, Jing Xu, Ye Li, Zhaosheng Wen, Xianzi Yao, Lihua Xie, Yuntao Deng, Dajun |
| description | Transcriptional inactivation of breast cancer gene 1 (BRCA1) by DNA methylation is a frequent event in sporadic breast cancers. To investigate whether BRCA1 methylation is associated with survival in Chinese patients with sporadic breast cancer, BRCA1 methylation was determined using methylation specific PCR in 536 sporadic breast cancers. Survival curves for patients with methylated and unmethylated BRCA1 were compared using the log‐rank tests. Twenty‐six percent (139/536) of patients exhibited BRCA1 methylation in their tumors. The degree of BRCA1 methylation was correlated with clinical stages of breast cancer, but was not significant. Patients with BRCA1 methylated tumors had a significantly worse 5‐year disease‐free survival (DFS) and 5‐year disease‐specific survival (DSS) than did patients with unmethylated tumors (DFS: 73.2%vs 82.6%, P = 0.045; DSS 80.5%vs 87%, P = 0.038, two‐sided). In conclusions, BRCA1 methylation is a frequent event in breast cancer and is associated with poor clinical outcome in Chinese women with breast cancer. (Cancer Sci 2009; 100: 1663–1667) |
| doi_str_mv | 10.1111/j.1349-7006.2009.01225.x |
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To investigate whether BRCA1 methylation is associated with survival in Chinese patients with sporadic breast cancer, BRCA1 methylation was determined using methylation specific PCR in 536 sporadic breast cancers. Survival curves for patients with methylated and unmethylated BRCA1 were compared using the log‐rank tests. Twenty‐six percent (139/536) of patients exhibited BRCA1 methylation in their tumors. The degree of BRCA1 methylation was correlated with clinical stages of breast cancer, but was not significant. Patients with BRCA1 methylated tumors had a significantly worse 5‐year disease‐free survival (DFS) and 5‐year disease‐specific survival (DSS) than did patients with unmethylated tumors (DFS: 73.2%vs 82.6%, P = 0.045; DSS 80.5%vs 87%, P = 0.038, two‐sided). In conclusions, BRCA1 methylation is a frequent event in breast cancer and is associated with poor clinical outcome in Chinese women with breast cancer. (Cancer Sci 2009; 100: 1663–1667)</description><identifier>ISSN: 1347-9032</identifier><identifier>ISSN: 1349-7006</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2009.01225.x</identifier><identifier>PMID: 19522853</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adenocarcinoma, Mucinous - genetics ; Adenocarcinoma, Mucinous - mortality ; Adult ; Aged ; Aged, 80 and over ; BRCA1 Protein - genetics ; Breast Neoplasms - genetics ; Breast Neoplasms - mortality ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - mortality ; Carcinoma, Lobular - genetics ; Carcinoma, Lobular - mortality ; DNA Methylation ; DNA, Neoplasm - genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Neoplasm Staging ; Original ; Polymerase Chain Reaction ; Prognosis ; Promoter Regions, Genetic - genetics ; Survival Rate</subject><ispartof>Cancer science, 2009-09, Vol.100 (9), p.1663-1667</ispartof><rights>2009 Japanese Cancer Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5075-fc3d91bf0a80c3373d7bfa039d992c817f3056516f423f306f9428aa0c841343</citedby><cites>FETCH-LOGICAL-c5075-fc3d91bf0a80c3373d7bfa039d992c817f3056516f423f306f9428aa0c841343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11158407/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11158407/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2009.01225.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19522853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yanglin</creatorcontrib><creatorcontrib>Zhou, Jing</creatorcontrib><creatorcontrib>Xu, Ye</creatorcontrib><creatorcontrib>Li, Zhaosheng</creatorcontrib><creatorcontrib>Wen, Xianzi</creatorcontrib><creatorcontrib>Yao, Lihua</creatorcontrib><creatorcontrib>Xie, Yuntao</creatorcontrib><creatorcontrib>Deng, Dajun</creatorcontrib><title>BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Transcriptional inactivation of breast cancer gene 1 (BRCA1) by DNA methylation is a frequent event in sporadic breast cancers. To investigate whether BRCA1 methylation is associated with survival in Chinese patients with sporadic breast cancer, BRCA1 methylation was determined using methylation specific PCR in 536 sporadic breast cancers. Survival curves for patients with methylated and unmethylated BRCA1 were compared using the log‐rank tests. Twenty‐six percent (139/536) of patients exhibited BRCA1 methylation in their tumors. The degree of BRCA1 methylation was correlated with clinical stages of breast cancer, but was not significant. Patients with BRCA1 methylated tumors had a significantly worse 5‐year disease‐free survival (DFS) and 5‐year disease‐specific survival (DSS) than did patients with unmethylated tumors (DFS: 73.2%vs 82.6%, P = 0.045; DSS 80.5%vs 87%, P = 0.038, two‐sided). In conclusions, BRCA1 methylation is a frequent event in breast cancer and is associated with poor clinical outcome in Chinese women with breast cancer. (Cancer Sci 2009; 100: 1663–1667)</description><subject>Adenocarcinoma, Mucinous - genetics</subject><subject>Adenocarcinoma, Mucinous - mortality</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>BRCA1 Protein - genetics</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - mortality</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - mortality</subject><subject>Carcinoma, Lobular - genetics</subject><subject>Carcinoma, Lobular - mortality</subject><subject>DNA Methylation</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Original</subject><subject>Polymerase Chain Reaction</subject><subject>Prognosis</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Survival Rate</subject><issn>1347-9032</issn><issn>1349-7006</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EoqXwF5BX7BKuX3G8QGiIykOqhATdWx7HIR4lcbAz086_x-mMCqzAGx_pfvf4Xh-EMIGS5PN2VxLGVSEBqpICqBIIpaK8f4IuHwtPH7QsFDB6gV6ktANgFVf8ObogSlBaC3aJ-g_fmg3BcwxjWFzEo1v642AWHyZsUgrWm8W1-M4vPZ5DiDjt48EfzID9hJveTy45PGfeTUs6YWkO0bTe4m10Ji3Ymsm6-BI968yQ3KvzfYVuP17fNp-Lm6-fvjSbm8IKkKLoLGsV2XZgarCMSdbKbWeAqVYpamsiOwaiEqTqOGVZV53itDYGbM3zuuwKvT_Zzvvt6Fqbx4pm0HP0o4lHHYzXf1cm3-sf4aDzt4qag8wOb84OMfzcu7To0SfrhsFMLuyTrqRQSkn6T5ASKjgnVQbrE2hjSCm67nEcAuu7RO_0GpteY9NrnvohT32fW1__uc7vxnOAGXh3Au784I7_baybzfdVsV8MKrA_</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Chen, Yanglin</creator><creator>Zhou, Jing</creator><creator>Xu, Ye</creator><creator>Li, Zhaosheng</creator><creator>Wen, Xianzi</creator><creator>Yao, Lihua</creator><creator>Xie, Yuntao</creator><creator>Deng, Dajun</creator><general>Blackwell Publishing Asia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200909</creationdate><title>BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer</title><author>Chen, Yanglin ; Zhou, Jing ; Xu, Ye ; Li, Zhaosheng ; Wen, Xianzi ; Yao, Lihua ; Xie, Yuntao ; Deng, Dajun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5075-fc3d91bf0a80c3373d7bfa039d992c817f3056516f423f306f9428aa0c841343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenocarcinoma, Mucinous - genetics</topic><topic>Adenocarcinoma, Mucinous - mortality</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>BRCA1 Protein - genetics</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - mortality</topic><topic>Carcinoma, Ductal, Breast - genetics</topic><topic>Carcinoma, Ductal, Breast - mortality</topic><topic>Carcinoma, Lobular - genetics</topic><topic>Carcinoma, Lobular - mortality</topic><topic>DNA Methylation</topic><topic>DNA, Neoplasm - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Original</topic><topic>Polymerase Chain Reaction</topic><topic>Prognosis</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yanglin</creatorcontrib><creatorcontrib>Zhou, Jing</creatorcontrib><creatorcontrib>Xu, Ye</creatorcontrib><creatorcontrib>Li, Zhaosheng</creatorcontrib><creatorcontrib>Wen, Xianzi</creatorcontrib><creatorcontrib>Yao, Lihua</creatorcontrib><creatorcontrib>Xie, Yuntao</creatorcontrib><creatorcontrib>Deng, Dajun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chen, Yanglin</au><au>Zhou, Jing</au><au>Xu, Ye</au><au>Li, Zhaosheng</au><au>Wen, Xianzi</au><au>Yao, Lihua</au><au>Xie, Yuntao</au><au>Deng, Dajun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2009-09</date><risdate>2009</risdate><volume>100</volume><issue>9</issue><spage>1663</spage><epage>1667</epage><pages>1663-1667</pages><issn>1347-9032</issn><issn>1349-7006</issn><eissn>1349-7006</eissn><abstract>Transcriptional inactivation of breast cancer gene 1 (BRCA1) by DNA methylation is a frequent event in sporadic breast cancers. To investigate whether BRCA1 methylation is associated with survival in Chinese patients with sporadic breast cancer, BRCA1 methylation was determined using methylation specific PCR in 536 sporadic breast cancers. Survival curves for patients with methylated and unmethylated BRCA1 were compared using the log‐rank tests. Twenty‐six percent (139/536) of patients exhibited BRCA1 methylation in their tumors. The degree of BRCA1 methylation was correlated with clinical stages of breast cancer, but was not significant. Patients with BRCA1 methylated tumors had a significantly worse 5‐year disease‐free survival (DFS) and 5‐year disease‐specific survival (DSS) than did patients with unmethylated tumors (DFS: 73.2%vs 82.6%, P = 0.045; DSS 80.5%vs 87%, P = 0.038, two‐sided). In conclusions, BRCA1 methylation is a frequent event in breast cancer and is associated with poor clinical outcome in Chinese women with breast cancer. (Cancer Sci 2009; 100: 1663–1667)</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19522853</pmid><doi>10.1111/j.1349-7006.2009.01225.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - mortality Adult Aged Aged, 80 and over BRCA1 Protein - genetics Breast Neoplasms - genetics Breast Neoplasms - mortality Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - mortality Carcinoma, Lobular - genetics Carcinoma, Lobular - mortality DNA Methylation DNA, Neoplasm - genetics Female Gene Expression Regulation, Neoplastic Humans Middle Aged Neoplasm Staging Original Polymerase Chain Reaction Prognosis Promoter Regions, Genetic - genetics Survival Rate |
| title | BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer |
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