DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4+ T cells and CD8+ T cells

We report that HSP105, identified by serological identification of antigens by recombinant expression cloning (SEREX), is overexpressed in a variety of human cancers, including colorectal, pancreatic, thyroid, esophageal, and breast carcinoma, but is not expressed in normal tissues except for the te...

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Veröffentlicht in:	Cancer science 2005-10, Vol.96 (10), p.695-705
Hauptverfasser:	Miyazaki, Masafumi, Nakatsura, Tetsuya, Yokomine, Kazunori, Senju, Satoru, Monji, Mikio, Hosaka, Seiji, Komori, Hiroyuki, Yoshitake, Yoshihiro, Motomura, Yutaka, Minohara, Motozumi, Kubo, Tatsuko, Ishihara, Keiichi, Hatayama, Takumi, Ogawa, Michio, Nishimura, Yasuharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm Biological and medical sciences CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen HSP110 Heat-Shock Proteins - biosynthesis HSP110 Heat-Shock Proteins - genetics Immunotherapy - methods Medical sciences Melanoma - pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasms, Experimental Original Skin Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Vaccines, DNA - immunology
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