Role of the RUNX1‐EVI1 fusion gene in leukemogenesis

RUNX1‐EVI1 is a chimeric gene generated by t(3;21)(q26;q22) observed in patients with aggressive transformation of myelodysplastic syndrome or chronic myelogenous leukemia. RUNX1‐EVI1 has oncogenic potentials through dominant‐negative effect over wild‐type RUNX1, inhibition of Jun kinase (JNK) pathw...

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Veröffentlicht in:	Cancer science 2008-10, Vol.99 (10), p.1878-1883
Hauptverfasser:	Maki, Kazuhiro, Yamagata, Tetsuya, Mitani, Kinuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - physiology Animals Biological and medical sciences Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 3 Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism DNA-Binding Proteins - physiology Humans Leukemia - genetics MDS1 and EVI1 Complex Locus Protein Medical sciences Mice Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Proto-Oncogenes Review Transcription Factors Translocation, Genetic Tumors
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