HLA‐A2‐restricted glypican‐3 peptide‐specific CTL clones induced by peptide vaccine show high avidity and antigen‐specific killing activity against tumor cells

Glypican‐3 (GPC3) is an onco‐fetal antigen that is overexpressed in human hepatocellular carcinoma (HCC), and is only expressed in the placenta and embryonic liver among normal tissues. Previously, we identified an HLA‐A2‐restricted GPC3144–152 (FVGEFFTDV) peptide that can induce GPC3‐reactive CTLs...

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Veröffentlicht in:	Cancer science 2011-05, Vol.102 (5), p.918-925
Hauptverfasser:	Yoshikawa, Toshiaki, Nakatsugawa, Munehide, Suzuki, Shiro, Shirakawa, Hirofumi, Nobuoka, Daisuke, Sakemura, Noriko, Motomura, Yutaka, Tanaka, Yukie, Hayashi, Shin‐Ichi, Nakatsura, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibody Affinity Biological and medical sciences Cancer Vaccines - immunology Cancer Vaccines - therapeutic use Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Cell Separation Clone Cells Cytotoxicity, Immunologic - immunology Female Flow Cytometry Glypicans - immunology HLA-A2 Antigen - immunology Humans Liver Neoplasms - immunology Liver Neoplasms - pathology Liver Neoplasms - therapy Male Medical sciences Middle Aged Neoplasm Staging Original T-Lymphocytes, Cytotoxic - immunology Tumors Vaccines, Subunit - immunology Vaccines, Subunit - therapeutic use
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