Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells
Neuroendocrine neoplasms can produce multiple hormones that are released into the bloodstream, causing symptoms that vary depending on the type and quantity of hormones involved. We herein report a 63-year-old asymptomatic patient with pancreatic insulinoma who showed marked elevations in circulatin...
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| Veröffentlicht in: | Internal Medicine 2024/05/15, Vol.63(10), pp.1415-1420 |
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| container_title | Internal Medicine |
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| creator | Kaketaka, Tomoko Mineo, Ikuo Kimura, Yu Ito, Naohiko Okauchi, Yukiyoshi Tamura, Hiromi Adachi, Shiro Iwahashi, Hiromi |
| description | Neuroendocrine neoplasms can produce multiple hormones that are released into the bloodstream, causing symptoms that vary depending on the type and quantity of hormones involved. We herein report a 63-year-old asymptomatic patient with pancreatic insulinoma who showed marked elevations in circulating calcitonin and procalcitonin levels that returned to normal following surgery. Immunohistochemical analyses confirmed the co-staining of calcitonin and insulin immunoreactivity in the tumor cells, suggesting a calcitonin-producing insulinoma. This insulinoma released calcitonin and a considerable amount of its precursor peptide, procalcitonin, resulting in both hyperprocalcitoninemia and hypercalcitoninemia. |
| doi_str_mv | 10.2169/internalmedicine.1565-23 |
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We herein report a 63-year-old asymptomatic patient with pancreatic insulinoma who showed marked elevations in circulating calcitonin and procalcitonin levels that returned to normal following surgery. Immunohistochemical analyses confirmed the co-staining of calcitonin and insulin immunoreactivity in the tumor cells, suggesting a calcitonin-producing insulinoma. This insulinoma released calcitonin and a considerable amount of its precursor peptide, procalcitonin, resulting in both hyperprocalcitoninemia and hypercalcitoninemia.</description><identifier>ISSN: 0918-2918</identifier><identifier>ISSN: 1349-7235</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.1565-23</identifier><identifier>PMID: 37839887</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Calcitonin ; Calcitonin - blood ; Case Report ; Female ; Humans ; Immunoreactivity ; Insulin ; Insulin - blood ; Insulinoma ; Insulinoma - blood ; Insulinoma - diagnosis ; Insulinoma - metabolism ; Male ; Middle Aged ; NEN ; Neuroendocrine tumors ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - diagnosis ; Procalcitonin ; Procalcitonin - blood ; proinsulin ; Tumor cells</subject><ispartof>Internal Medicine, 2024/05/15, Vol.63(10), pp.1415-1420</ispartof><rights>2024 by The Japanese Society of Internal Medicine</rights><rights>2024. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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Med.</addtitle><description>Neuroendocrine neoplasms can produce multiple hormones that are released into the bloodstream, causing symptoms that vary depending on the type and quantity of hormones involved. We herein report a 63-year-old asymptomatic patient with pancreatic insulinoma who showed marked elevations in circulating calcitonin and procalcitonin levels that returned to normal following surgery. Immunohistochemical analyses confirmed the co-staining of calcitonin and insulin immunoreactivity in the tumor cells, suggesting a calcitonin-producing insulinoma. This insulinoma released calcitonin and a considerable amount of its precursor peptide, procalcitonin, resulting in both hyperprocalcitoninemia and hypercalcitoninemia.</description><subject>Calcitonin</subject><subject>Calcitonin - blood</subject><subject>Case Report</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoreactivity</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulinoma</subject><subject>Insulinoma - blood</subject><subject>Insulinoma - diagnosis</subject><subject>Insulinoma - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NEN</subject><subject>Neuroendocrine tumors</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Procalcitonin</subject><subject>Procalcitonin - blood</subject><subject>proinsulin</subject><subject>Tumor cells</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkcFu1DAQhiMEokvhFZAlLlxSbE-c2CeEVtCuVKkHytmadby7XiV2sBNKbzx6E7JEsEjWWPJ888-M_ywjjF5xVqoPzvc2emxaWzvjvL1iohQ5h2fZikGh8oqDeJ6tqGIy52O4yF6ldKQUZKX4y-wCKglKymqV_dr4NDTOhxbJg-sP5Oaxs7GLwWBjXB_8qN46JOjrOXX2_vUQHpzfk3WwP7toU3LBk7AjJ9nfdeulhIxn0ydyP7QhkrVtmvQ6e7HDJtk3p_sy-_bl8_36Jr-9u96sP93mRgDvc1Aot1ZxVFsEQ20BdcV2VCgjBBSlrEuLNSqolDAVSkolFqBEwWRtOCiAy-zjrNsN2_HbjPV9xEZ30bUYH3VAp__NeHfQ-_BDM8ZEBbwYFd6fFGL4PtjU69YlM-6A3oYhaS4rSZlkakLfnaHHMEyGJQ20lMCEKKaR5EyZGFKKdrdMw6iefNbnPuvJZ82n0rd_b7MU_jF2BO5m4Jh63NsFwNg709j_lUuYuk5xbrGQ5oBRWw9PJn3J7Q</recordid><startdate>20240515</startdate><enddate>20240515</enddate><creator>Kaketaka, Tomoko</creator><creator>Mineo, Ikuo</creator><creator>Kimura, Yu</creator><creator>Ito, Naohiko</creator><creator>Okauchi, Yukiyoshi</creator><creator>Tamura, Hiromi</creator><creator>Adachi, Shiro</creator><creator>Iwahashi, Hiromi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240515</creationdate><title>Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells</title><author>Kaketaka, Tomoko ; Mineo, Ikuo ; Kimura, Yu ; Ito, Naohiko ; Okauchi, Yukiyoshi ; Tamura, Hiromi ; Adachi, Shiro ; Iwahashi, Hiromi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-39a8be92a9ba3c0e43d71f059c553468d6eada93795c7a8008a4395418dc23933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Calcitonin</topic><topic>Calcitonin - blood</topic><topic>Case Report</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoreactivity</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulinoma</topic><topic>Insulinoma - blood</topic><topic>Insulinoma - diagnosis</topic><topic>Insulinoma - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>NEN</topic><topic>Neuroendocrine tumors</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>Procalcitonin</topic><topic>Procalcitonin - blood</topic><topic>proinsulin</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaketaka, Tomoko</creatorcontrib><creatorcontrib>Mineo, Ikuo</creatorcontrib><creatorcontrib>Kimura, Yu</creatorcontrib><creatorcontrib>Ito, Naohiko</creatorcontrib><creatorcontrib>Okauchi, Yukiyoshi</creatorcontrib><creatorcontrib>Tamura, Hiromi</creatorcontrib><creatorcontrib>Adachi, Shiro</creatorcontrib><creatorcontrib>Iwahashi, Hiromi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaketaka, Tomoko</au><au>Mineo, Ikuo</au><au>Kimura, Yu</au><au>Ito, Naohiko</au><au>Okauchi, Yukiyoshi</au><au>Tamura, Hiromi</au><au>Adachi, Shiro</au><au>Iwahashi, Hiromi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2024-05-15</date><risdate>2024</risdate><volume>63</volume><issue>10</issue><spage>1415</spage><epage>1420</epage><pages>1415-1420</pages><artnum>1565-23</artnum><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>Neuroendocrine neoplasms can produce multiple hormones that are released into the bloodstream, causing symptoms that vary depending on the type and quantity of hormones involved. We herein report a 63-year-old asymptomatic patient with pancreatic insulinoma who showed marked elevations in circulating calcitonin and procalcitonin levels that returned to normal following surgery. Immunohistochemical analyses confirmed the co-staining of calcitonin and insulin immunoreactivity in the tumor cells, suggesting a calcitonin-producing insulinoma. 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| subjects | Calcitonin Calcitonin - blood Case Report Female Humans Immunoreactivity Insulin Insulin - blood Insulinoma Insulinoma - blood Insulinoma - diagnosis Insulinoma - metabolism Male Middle Aged NEN Neuroendocrine tumors Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Procalcitonin Procalcitonin - blood proinsulin Tumor cells |
| title | Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells |
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