BA.5 sub-lineages associated with higher severity of COVID-19 infection: A cross-sectional study in Indonesia
•BA.1 and BA.2 were the sub-lineages of Omicron with milder symptoms.•BA.5 sub-lineages were associated with more severe symptoms.•Booster vaccinations reduced poor outcomes in Omicron infections.•People with multiple comorbidities had the highest risk of contracting severe COVID-19. We aimed to com...
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| Veröffentlicht in: | IJID regions 2024-06, Vol.11, p.100379-100379, Article 100379 |
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| creator | Hartantri, Yovita Andriyoko, Basti Debora, Josephine Rachman, Febi Ramdhani Susandi, Evan Ferdian, Ferdy Ganiem, Ahmad Rizal Alisjahbana, Bachti Soeroto, Arto Yuwono Turbawaty, Dewi Kartika |
| description | •BA.1 and BA.2 were the sub-lineages of Omicron with milder symptoms.•BA.5 sub-lineages were associated with more severe symptoms.•Booster vaccinations reduced poor outcomes in Omicron infections.•People with multiple comorbidities had the highest risk of contracting severe COVID-19.
We aimed to compare the clinical severity and outcome among laboratory-confirmed Omicron variant cases admitted between January and December 2022.
This is a cross-sectional study conducted in Hasan Sadikin General Hospital between January and December 2022. We enrolled patients aged ≥18 years with laboratory-confirmed Omicron infection. Data were collected from clinical records and a whole genome sequencing database. We compared the risk of severe symptoms and mortality using a logistic regression analysis adjusted for sex, age, comorbidities, and vaccination status.
We enrolled 255 patients and the main sub-lineages were BA.1 (16.1%), BA.2 (11.4%), BA.5 (35.7%), XBB (22.7%), and BQ.1 (14.1%). Compared with BA.1/BA.2, BA.5 sub-lineages were associated with severe symptoms (adjusted odds ratio of 2.9, 95% confidence interval 1.1-8.2, P |
| doi_str_mv | 10.1016/j.ijregi.2024.100379 |
| format | Article |
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We aimed to compare the clinical severity and outcome among laboratory-confirmed Omicron variant cases admitted between January and December 2022.
This is a cross-sectional study conducted in Hasan Sadikin General Hospital between January and December 2022. We enrolled patients aged ≥18 years with laboratory-confirmed Omicron infection. Data were collected from clinical records and a whole genome sequencing database. We compared the risk of severe symptoms and mortality using a logistic regression analysis adjusted for sex, age, comorbidities, and vaccination status.
We enrolled 255 patients and the main sub-lineages were BA.1 (16.1%), BA.2 (11.4%), BA.5 (35.7%), XBB (22.7%), and BQ.1 (14.1%). Compared with BA.1/BA.2, BA.5 sub-lineages were associated with severe symptoms (adjusted odds ratio of 2.9, 95% confidence interval 1.1-8.2, P <0.05). The highest risk of severe symptoms and mortality was linked with a high number of comorbidities (adjusted odds ratio of 7.8, 95% confidence interval 1.7-22.4, P <0.05). Booster vaccination was protective of severity and mortality.
Disease severity was associated with BA.5 sub-lineages and multiple comorbidities. Good management is particularly important for people with comorbidities. Furthermore, booster vaccination is also required to reduce severity and mortality.</description><identifier>ISSN: 2772-7076</identifier><identifier>EISSN: 2772-7076</identifier><identifier>DOI: 10.1016/j.ijregi.2024.100379</identifier><identifier>PMID: 38855022</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Mortality ; Omicron ; Original Report ; SARS-CoV-2 ; Severity ; Sub-variants</subject><ispartof>IJID regions, 2024-06, Vol.11, p.100379-100379, Article 100379</ispartof><rights>2024 The Authors</rights><rights>2024 The Authors.</rights><rights>2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c413t-a0461d83af7b993f1f70c2d8e8df7ef24486dd32a8504e7c4449d75e3a25f0a33</cites><orcidid>0000-0001-9633-6518</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157273/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157273/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38855022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hartantri, Yovita</creatorcontrib><creatorcontrib>Andriyoko, Basti</creatorcontrib><creatorcontrib>Debora, Josephine</creatorcontrib><creatorcontrib>Rachman, Febi Ramdhani</creatorcontrib><creatorcontrib>Susandi, Evan</creatorcontrib><creatorcontrib>Ferdian, Ferdy</creatorcontrib><creatorcontrib>Ganiem, Ahmad Rizal</creatorcontrib><creatorcontrib>Alisjahbana, Bachti</creatorcontrib><creatorcontrib>Soeroto, Arto Yuwono</creatorcontrib><creatorcontrib>Turbawaty, Dewi Kartika</creatorcontrib><title>BA.5 sub-lineages associated with higher severity of COVID-19 infection: A cross-sectional study in Indonesia</title><title>IJID regions</title><addtitle>IJID Reg</addtitle><description>•BA.1 and BA.2 were the sub-lineages of Omicron with milder symptoms.•BA.5 sub-lineages were associated with more severe symptoms.•Booster vaccinations reduced poor outcomes in Omicron infections.•People with multiple comorbidities had the highest risk of contracting severe COVID-19.
We aimed to compare the clinical severity and outcome among laboratory-confirmed Omicron variant cases admitted between January and December 2022.
This is a cross-sectional study conducted in Hasan Sadikin General Hospital between January and December 2022. We enrolled patients aged ≥18 years with laboratory-confirmed Omicron infection. Data were collected from clinical records and a whole genome sequencing database. We compared the risk of severe symptoms and mortality using a logistic regression analysis adjusted for sex, age, comorbidities, and vaccination status.
We enrolled 255 patients and the main sub-lineages were BA.1 (16.1%), BA.2 (11.4%), BA.5 (35.7%), XBB (22.7%), and BQ.1 (14.1%). Compared with BA.1/BA.2, BA.5 sub-lineages were associated with severe symptoms (adjusted odds ratio of 2.9, 95% confidence interval 1.1-8.2, P <0.05). The highest risk of severe symptoms and mortality was linked with a high number of comorbidities (adjusted odds ratio of 7.8, 95% confidence interval 1.7-22.4, P <0.05). Booster vaccination was protective of severity and mortality.
Disease severity was associated with BA.5 sub-lineages and multiple comorbidities. Good management is particularly important for people with comorbidities. Furthermore, booster vaccination is also required to reduce severity and mortality.</description><subject>Mortality</subject><subject>Omicron</subject><subject>Original Report</subject><subject>SARS-CoV-2</subject><subject>Severity</subject><subject>Sub-variants</subject><issn>2772-7076</issn><issn>2772-7076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kU1vEzEQhlcIRKvSf4CQj1w2-HO9ywEUwlekSr0AV8uxx8lEG7vYu0H592zYUpULpxmN33lnPE9VvWR0wShr3uwXuM-wxQWnXE4lKnT3pLrkWvNaU908fZRfVNel7CmlXHeSCv68uhBtqxTl_LI6fFguFCnjpu4xgt1CIbaU5NAO4MkvHHZkh9sdZFLgCBmHE0mBrG5_rD_WrCMYA7gBU3xLlsTlVEpd5oLtSRlGf5okZB19ilDQvqieBdsXuL6PV9X3z5--rb7WN7df1qvlTe0kE0NtqWyYb4UNetN1IrCgqeO-hdYHDYFL2TbeC25bRSVoJ6XsvFYgLFeBWiGuqvez7924OYB3EIdse3OX8WDzySSL5t-XiDuzTUfDGFOa67PD63uHnH6OUAZzwOKg722ENBYjaNMIoZSUk1TO0j__zxAe5jBqzrTM3sy0zJmWmWlNba8e7_jQ9JfNJHg3C2C61BEhm-IQogOPebqx8Qn_P-E36JWoHw</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Hartantri, Yovita</creator><creator>Andriyoko, Basti</creator><creator>Debora, Josephine</creator><creator>Rachman, Febi Ramdhani</creator><creator>Susandi, Evan</creator><creator>Ferdian, Ferdy</creator><creator>Ganiem, Ahmad Rizal</creator><creator>Alisjahbana, Bachti</creator><creator>Soeroto, Arto Yuwono</creator><creator>Turbawaty, Dewi Kartika</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9633-6518</orcidid></search><sort><creationdate>20240601</creationdate><title>BA.5 sub-lineages associated with higher severity of COVID-19 infection: A cross-sectional study in Indonesia</title><author>Hartantri, Yovita ; Andriyoko, Basti ; Debora, Josephine ; Rachman, Febi Ramdhani ; Susandi, Evan ; Ferdian, Ferdy ; Ganiem, Ahmad Rizal ; Alisjahbana, Bachti ; Soeroto, Arto Yuwono ; Turbawaty, Dewi Kartika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-a0461d83af7b993f1f70c2d8e8df7ef24486dd32a8504e7c4449d75e3a25f0a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Mortality</topic><topic>Omicron</topic><topic>Original Report</topic><topic>SARS-CoV-2</topic><topic>Severity</topic><topic>Sub-variants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hartantri, Yovita</creatorcontrib><creatorcontrib>Andriyoko, Basti</creatorcontrib><creatorcontrib>Debora, Josephine</creatorcontrib><creatorcontrib>Rachman, Febi Ramdhani</creatorcontrib><creatorcontrib>Susandi, Evan</creatorcontrib><creatorcontrib>Ferdian, Ferdy</creatorcontrib><creatorcontrib>Ganiem, Ahmad Rizal</creatorcontrib><creatorcontrib>Alisjahbana, Bachti</creatorcontrib><creatorcontrib>Soeroto, Arto Yuwono</creatorcontrib><creatorcontrib>Turbawaty, Dewi Kartika</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>IJID regions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hartantri, Yovita</au><au>Andriyoko, Basti</au><au>Debora, Josephine</au><au>Rachman, Febi Ramdhani</au><au>Susandi, Evan</au><au>Ferdian, Ferdy</au><au>Ganiem, Ahmad Rizal</au><au>Alisjahbana, Bachti</au><au>Soeroto, Arto Yuwono</au><au>Turbawaty, Dewi Kartika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BA.5 sub-lineages associated with higher severity of COVID-19 infection: A cross-sectional study in Indonesia</atitle><jtitle>IJID regions</jtitle><addtitle>IJID Reg</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>11</volume><spage>100379</spage><epage>100379</epage><pages>100379-100379</pages><artnum>100379</artnum><issn>2772-7076</issn><eissn>2772-7076</eissn><abstract>•BA.1 and BA.2 were the sub-lineages of Omicron with milder symptoms.•BA.5 sub-lineages were associated with more severe symptoms.•Booster vaccinations reduced poor outcomes in Omicron infections.•People with multiple comorbidities had the highest risk of contracting severe COVID-19.
We aimed to compare the clinical severity and outcome among laboratory-confirmed Omicron variant cases admitted between January and December 2022.
This is a cross-sectional study conducted in Hasan Sadikin General Hospital between January and December 2022. We enrolled patients aged ≥18 years with laboratory-confirmed Omicron infection. Data were collected from clinical records and a whole genome sequencing database. We compared the risk of severe symptoms and mortality using a logistic regression analysis adjusted for sex, age, comorbidities, and vaccination status.
We enrolled 255 patients and the main sub-lineages were BA.1 (16.1%), BA.2 (11.4%), BA.5 (35.7%), XBB (22.7%), and BQ.1 (14.1%). Compared with BA.1/BA.2, BA.5 sub-lineages were associated with severe symptoms (adjusted odds ratio of 2.9, 95% confidence interval 1.1-8.2, P <0.05). The highest risk of severe symptoms and mortality was linked with a high number of comorbidities (adjusted odds ratio of 7.8, 95% confidence interval 1.7-22.4, P <0.05). Booster vaccination was protective of severity and mortality.
Disease severity was associated with BA.5 sub-lineages and multiple comorbidities. Good management is particularly important for people with comorbidities. Furthermore, booster vaccination is also required to reduce severity and mortality.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38855022</pmid><doi>10.1016/j.ijregi.2024.100379</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9633-6518</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2772-7076 |
| ispartof | IJID regions, 2024-06, Vol.11, p.100379-100379, Article 100379 |
| issn | 2772-7076 2772-7076 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11157273 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Mortality Omicron Original Report SARS-CoV-2 Severity Sub-variants |
| title | BA.5 sub-lineages associated with higher severity of COVID-19 infection: A cross-sectional study in Indonesia |
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