Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma

Programmed cell death mechanisms are important for the regulation of tumor development and progression. Evasion of and resistance to apoptosis are significant factors in tumorigenesis and drug resistance. Bypassing apoptotic pathways and eliciting another form of regulated cell death, namely necropt...

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Veröffentlicht in:	Cancer research communications 2024-06, Vol.4 (6), p.1441-1453
Hauptverfasser:	Ward, George A, Zhang, Zhiqiang, Jueliger, Simone, Potapov, Ilya S, Davis, Matthew P, Boxall, Adam R, Taylor, Jason, Keer, Harold, Biondo, Andrea, Lyons, John F, Sims, Martin, Smyth, Tomoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell Death And Senescence Cell Line, Tumor Decitabine - pharmacology Decitabine - therapeutic use DNA Methylation - drug effects Drug Mechanisms Epigenesis, Genetic - drug effects Epigenetics Hematological Cancers Humans Lymphoma, T-Cell - drug therapy Lymphoma, T-Cell - genetics Lymphoma, T-Cell - immunology Lymphoma, T-Cell - pathology Mice Necroptosis - drug effects Small Molecule Agents Translational Research
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