Detecting partial premature ovulation during follicular aspiration compromises the quantity, but not the quality, of the oocytes retrieved in stimulated in vitro fertilization (IVF) cycles
To analyze if partial premature ovulation (PPO) detection during oocyte pick-up (OPU) impairs the quality of the retrieved oocyte cohort. The PPO concept refers to the situation when premature ovulation happens only in some of the follicles and it is detected during OPU. This study constitutes a ret...
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| Veröffentlicht in: | JBRA assisted reproduction 2024, Vol.28 (2), p.240-246 |
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| creator | Gómez, Víctor Hugo Rodríguez-Varela, Cristina Labarta, Elena Bosch, Ernesto |
| description | To analyze if partial premature ovulation (PPO) detection during oocyte pick-up (OPU) impairs the quality of the retrieved oocyte cohort.
The PPO concept refers to the situation when premature ovulation happens only in some of the follicles and it is detected during OPU. This study constitutes a retrospective analysis performed in an infertility clinic (Spain) during 2016-2021 with patients undergoing OPU after controlled ovarian hyperstimulation for an in vitro fertilization (IVF) treatment. Study code: 2110-VLC-091- VG, registered on December 9 2021. Data from women with PPO (n=111) were compared to a matched control sample of cycles without PPO (n=333) at a proportion of 1:3.
Cycles were matched for age, body mass index (BMI), treatment year, embryo genetic analysis and stimulation protocol type. The mean numbers of oocytes (6.1 vs. 11.2), mature oocytes (4.7 vs. 8.8), correctly fertilized oocytes (3.6 vs. 6.6) and top-quality blastocysts (0.9 vs. 1.8) were significantly lower in the PPO group than the nonPPO group (p0.05).
Cycles with PPO have fewer available oocytes and, thus, fewer available embryos for transfer, al though their quality is intact, and still offer chances of pregnancy in these cases. Hence cycle cancellation may not be worth associated money, time and morale losses once PPO is detected. |
| doi_str_mv | 10.5935/1518-0557.20240003 |
| format | Article |
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The PPO concept refers to the situation when premature ovulation happens only in some of the follicles and it is detected during OPU. This study constitutes a retrospective analysis performed in an infertility clinic (Spain) during 2016-2021 with patients undergoing OPU after controlled ovarian hyperstimulation for an in vitro fertilization (IVF) treatment. Study code: 2110-VLC-091- VG, registered on December 9 2021. Data from women with PPO (n=111) were compared to a matched control sample of cycles without PPO (n=333) at a proportion of 1:3.
Cycles were matched for age, body mass index (BMI), treatment year, embryo genetic analysis and stimulation protocol type. The mean numbers of oocytes (6.1 vs. 11.2), mature oocytes (4.7 vs. 8.8), correctly fertilized oocytes (3.6 vs. 6.6) and top-quality blastocysts (0.9 vs. 1.8) were significantly lower in the PPO group than the nonPPO group (p<0.05). However, maturation, fertilization, top-quality blastocyst and pregnancy rates were statistically comparable among groups (p>0.05).
Cycles with PPO have fewer available oocytes and, thus, fewer available embryos for transfer, al though their quality is intact, and still offer chances of pregnancy in these cases. Hence cycle cancellation may not be worth associated money, time and morale losses once PPO is detected.</description><identifier>ISSN: 1518-0557</identifier><identifier>ISSN: 1517-5693</identifier><identifier>EISSN: 1518-0557</identifier><identifier>DOI: 10.5935/1518-0557.20240003</identifier><identifier>PMID: 38289203</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</publisher><subject>Adult ; Embryology ; Female ; Fertilization in Vitro - methods ; Follicles ; Humans ; In vitro fertilization ; Infertility ; Miscarriage ; Oocyte Retrieval ; Oocytes - physiology ; Original ; Ovarian Follicle ; Ovaries ; Ovulation ; Ovulation - physiology ; Ovulation Induction - methods ; Pregnancy ; Retrospective Studies ; Ultrasonic imaging</subject><ispartof>JBRA assisted reproduction, 2024, Vol.28 (2), p.240-246</ispartof><rights>2024. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152434/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152434/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38289203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gómez, Víctor Hugo</creatorcontrib><creatorcontrib>Rodríguez-Varela, Cristina</creatorcontrib><creatorcontrib>Labarta, Elena</creatorcontrib><creatorcontrib>Bosch, Ernesto</creatorcontrib><title>Detecting partial premature ovulation during follicular aspiration compromises the quantity, but not the quality, of the oocytes retrieved in stimulated in vitro fertilization (IVF) cycles</title><title>JBRA assisted reproduction</title><addtitle>JBRA Assist Reprod</addtitle><description>To analyze if partial premature ovulation (PPO) detection during oocyte pick-up (OPU) impairs the quality of the retrieved oocyte cohort.
The PPO concept refers to the situation when premature ovulation happens only in some of the follicles and it is detected during OPU. This study constitutes a retrospective analysis performed in an infertility clinic (Spain) during 2016-2021 with patients undergoing OPU after controlled ovarian hyperstimulation for an in vitro fertilization (IVF) treatment. Study code: 2110-VLC-091- VG, registered on December 9 2021. Data from women with PPO (n=111) were compared to a matched control sample of cycles without PPO (n=333) at a proportion of 1:3.
Cycles were matched for age, body mass index (BMI), treatment year, embryo genetic analysis and stimulation protocol type. The mean numbers of oocytes (6.1 vs. 11.2), mature oocytes (4.7 vs. 8.8), correctly fertilized oocytes (3.6 vs. 6.6) and top-quality blastocysts (0.9 vs. 1.8) were significantly lower in the PPO group than the nonPPO group (p<0.05). However, maturation, fertilization, top-quality blastocyst and pregnancy rates were statistically comparable among groups (p>0.05).
Cycles with PPO have fewer available oocytes and, thus, fewer available embryos for transfer, al though their quality is intact, and still offer chances of pregnancy in these cases. Hence cycle cancellation may not be worth associated money, time and morale losses once PPO is detected.</description><subject>Adult</subject><subject>Embryology</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Follicles</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Miscarriage</subject><subject>Oocyte Retrieval</subject><subject>Oocytes - physiology</subject><subject>Original</subject><subject>Ovarian Follicle</subject><subject>Ovaries</subject><subject>Ovulation</subject><subject>Ovulation - physiology</subject><subject>Ovulation Induction - methods</subject><subject>Pregnancy</subject><subject>Retrospective Studies</subject><subject>Ultrasonic imaging</subject><issn>1518-0557</issn><issn>1517-5693</issn><issn>1518-0557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdUsFu1DAQjRCIVqU_wAFZ4lIktnjseOOcECoUKlXiAlwtrz1pXTlxajsrLd_Gx-E03VXh5Jk3b97MeKaqXgM9Fy0XH0CAXFEhmnNGWU0p5c-q4wP4_Il9VJ2mdFcY0ALjNX1ZHXHJZMsoP67-fMaMJrvhhow6Zqc9GSP2Ok8RSdhOXmcXBmKnOFO64L0zBYxEp9HFJWhCP8bQu4SJ5Fsk95Messu792QzZTKEvEf9Axi6Bz8Es8slI2KODrdoiRtIyq6fay7e1uUYSIelL-9-L8XOrn5dviNmZzymV9WLTvuEp4_vSfXz8suPi2-r6-9fry4-Xa9MGTSvOsZgDdpoy6yoGZMUtGSNbGwjJEra2s5KasVGguQgKDYWudFo1x2Cpi0_qT4uuuO06dEaHHLUXo3R9TruVNBO_RsZ3K26CVsFAILVvC4KZ48KMdxPmLIq32XQez1gmJJiZRsg14KuC_Xtf9S7MMWhzKc4bWoKogEoLLawTAwpRewO3QBV84Goef9q3r_aH0hJevN0jkPK_hz4X8yTuzY</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Gómez, Víctor Hugo</creator><creator>Rodríguez-Varela, Cristina</creator><creator>Labarta, Elena</creator><creator>Bosch, Ernesto</creator><general>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</general><general>Brazilian Society of Assisted Reproduction</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2024</creationdate><title>Detecting partial premature ovulation during follicular aspiration compromises the quantity, but not the quality, of the oocytes retrieved in stimulated in vitro fertilization (IVF) cycles</title><author>Gómez, Víctor Hugo ; Rodríguez-Varela, Cristina ; Labarta, Elena ; Bosch, Ernesto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-f22161acad2d5422801a82787d758e809dfd80d5b8183150e7de3caed6fe1a093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Embryology</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Follicles</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Miscarriage</topic><topic>Oocyte Retrieval</topic><topic>Oocytes - physiology</topic><topic>Original</topic><topic>Ovarian Follicle</topic><topic>Ovaries</topic><topic>Ovulation</topic><topic>Ovulation - physiology</topic><topic>Ovulation Induction - methods</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>Ultrasonic imaging</topic><toplevel>online_resources</toplevel><creatorcontrib>Gómez, Víctor Hugo</creatorcontrib><creatorcontrib>Rodríguez-Varela, Cristina</creatorcontrib><creatorcontrib>Labarta, Elena</creatorcontrib><creatorcontrib>Bosch, Ernesto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JBRA assisted reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez, Víctor Hugo</au><au>Rodríguez-Varela, Cristina</au><au>Labarta, Elena</au><au>Bosch, Ernesto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detecting partial premature ovulation during follicular aspiration compromises the quantity, but not the quality, of the oocytes retrieved in stimulated in vitro fertilization (IVF) cycles</atitle><jtitle>JBRA assisted reproduction</jtitle><addtitle>JBRA Assist Reprod</addtitle><date>2024</date><risdate>2024</risdate><volume>28</volume><issue>2</issue><spage>240</spage><epage>246</epage><pages>240-246</pages><issn>1518-0557</issn><issn>1517-5693</issn><eissn>1518-0557</eissn><abstract>To analyze if partial premature ovulation (PPO) detection during oocyte pick-up (OPU) impairs the quality of the retrieved oocyte cohort.
The PPO concept refers to the situation when premature ovulation happens only in some of the follicles and it is detected during OPU. This study constitutes a retrospective analysis performed in an infertility clinic (Spain) during 2016-2021 with patients undergoing OPU after controlled ovarian hyperstimulation for an in vitro fertilization (IVF) treatment. Study code: 2110-VLC-091- VG, registered on December 9 2021. Data from women with PPO (n=111) were compared to a matched control sample of cycles without PPO (n=333) at a proportion of 1:3.
Cycles were matched for age, body mass index (BMI), treatment year, embryo genetic analysis and stimulation protocol type. The mean numbers of oocytes (6.1 vs. 11.2), mature oocytes (4.7 vs. 8.8), correctly fertilized oocytes (3.6 vs. 6.6) and top-quality blastocysts (0.9 vs. 1.8) were significantly lower in the PPO group than the nonPPO group (p<0.05). However, maturation, fertilization, top-quality blastocyst and pregnancy rates were statistically comparable among groups (p>0.05).
Cycles with PPO have fewer available oocytes and, thus, fewer available embryos for transfer, al though their quality is intact, and still offer chances of pregnancy in these cases. Hence cycle cancellation may not be worth associated money, time and morale losses once PPO is detected.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</pub><pmid>38289203</pmid><doi>10.5935/1518-0557.20240003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Embryology Female Fertilization in Vitro - methods Follicles Humans In vitro fertilization Infertility Miscarriage Oocyte Retrieval Oocytes - physiology Original Ovarian Follicle Ovaries Ovulation Ovulation - physiology Ovulation Induction - methods Pregnancy Retrospective Studies Ultrasonic imaging |
| title | Detecting partial premature ovulation during follicular aspiration compromises the quantity, but not the quality, of the oocytes retrieved in stimulated in vitro fertilization (IVF) cycles |
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