Plasticity and lineage commitment of individual TH1 cells are determined by stable T-bet expression quantities

T helper 1 (TH1) cell identity is defined by the expression of the lineage-specifying transcription factor T-bet. Here, we examine the influence of T-bet expression heterogeneity on subset plasticity by leveraging cell sorting of distinct in vivo-differentiated TH1 cells based on their quantitative...

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Veröffentlicht in:	Science advances 2024-06, Vol.10 (23), p.eadk2693
Hauptverfasser:	Hegazy, Ahmed N, Peine, Caroline, Niesen, Dominik, Panse, Isabel, Vainshtein, Yevhen, Kommer, Christoph, Zhang, Qin, Brunner, Tobias M, Peine, Michael, Fröhlich, Anja, Ishaque, Naveed, Marek, Roman M, Zhu, Jinfang, Höfer, Thomas, Löhning, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine and Life Sciences Immunology Life Sciences SciAdv r-articles
Online-Zugang:	Volltext
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