Relationship between action potential, contraction-relaxation pattern, and intracellular Ca2+ transient in cardiomyocytes of dogs with chronic heart failure

Abnormalities of contractile function have been identified in cardiomyocytes isolated from failed human hearts and from hearts of animals with experimentally induced heart failure (HF). The mechanism(s) responsible for these functional abnormalities are not fully understood. In the present study, we...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 1998-06, Vol.54 (6), p.597-605
Hauptverfasser:	Maltsev, V A, Sabbah, H N, Tanimura, M, Lesch, M, Goldstein, S, Undrovinas, A I
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Calcium - metabolism Cardiomyocytes Cells, Cultured Cellular biology Disease Models, Animal Dogs Electrophysiology Heart - physiopathology Heart failure Heart Failure - physiopathology Lidocaine - pharmacology Muscle Contraction - physiology Saxitoxin - pharmacology
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