Decreased levels of complex III core protein 1 and complex V beta chain in brains from patients with Alzheimer's disease and Down syndrome

Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approa...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2000-11, Vol.57 (12), p.1810-1816
Hauptverfasser:	Kim, S H, Vlkolinsky, R, Cairns, N, Lubec, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - metabolism Adult Aged Alzheimer Disease - enzymology Alzheimer Disease - etiology Alzheimer Disease - pathology Apoptosis ATP synthase Brain - enzymology Carrier Proteins Case-Control Studies Down Syndrome - enzymology Down Syndrome - etiology Down Syndrome - pathology Electron Transport Complex III - chemistry Electron Transport Complex III - metabolism Energy Metabolism Humans Membrane Proteins - chemistry Membrane Proteins - metabolism Middle Aged Mitochondria - enzymology Mitochondrial Proton-Translocating ATPases Protein Subunits Proton-Translocating ATPases - chemistry Proton-Translocating ATPases - metabolism Qcr7 protein Reactive Oxygen Species - metabolism Tissue Distribution Vacuolar Proton-Translocating ATPases
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