dual role model for p53 in maintaining genomic integrity

The tumour suppressor p53 is a potent mediator of cellular responses against genotoxic insults. In this review we describe the multiple functions of p53 in response to DNA damage, with an emphasis on p53's role in DNA repair. We summarize data demonstrating that p53 actively participates in var...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 1999, Vol.55 (1), p.12-27
Hauptverfasser:	Janus, F, Albrechtsen, N, Dornreiter, I, Wiesmüller, L, Grosse, F, Deppert, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyribonucleic acid DNA DNA damage DNA Damage - genetics DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics Exodeoxyribonuclease V Exodeoxyribonucleases - genetics Gene Expression Regulation - genetics Genetics genome Genomes genotoxicity Inactivation neoplasms Recombination, Genetic - genetics Simian virus 40 - genetics transcriptional activation Tumor Suppressor Protein p53 - genetics
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