Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells

ABCC3 (also known as MRP3) is an ATP binding cassette transporter for bile acids, whose expression is downregulated in colorectal cancer through the Wnt/β‐catenin signaling pathway. However, it remained unclear how downregulation of ABCC3 expression contributes to colorectal carcinogenesis. We explo...

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Veröffentlicht in:	Cancer science 2024-06, Vol.115 (6), p.1778-1790
Hauptverfasser:	Sato, Yukihiro, Kobayashi, Minoru, Ohira, Masahiro, Funayama, Ryo, Maekawa, Masamitsu, Karasawa, Hideaki, Kashiwagi, Ryosuke, Aoyama, Yayoi, Mano, Nariyasu, Ohnuma, Shinobu, Unno, Michiaki, Nakayama, Keiko
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCC3 Acids Adenoma Adenomatous Polyposis Coli - genetics Adenomatous Polyposis Coli - metabolism Adenomatous Polyposis Coli - pathology Anti-inflammatory agents Bile Bile acids Carcinogenesis Cell Line, Tumor Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Deoxycholic acid Deoxycholic Acid - metabolism Deoxycholic Acid - pharmacology Down-Regulation Familial adenomatous polyposis Gene expression Gene Expression Regulation, Neoplastic Humans Inflammation Intracellular Intracellular signalling MAP kinase MAP Kinase Signaling System MAPK signaling MRP3 Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Mutation Nonsteroidal anti-inflammatory drugs Original Signal transduction Software Statistical analysis Tumors Wnt protein β-Catenin
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