Molecular mechanisms of N-acetylcysteine actions

Oxidative stress generated by an imbalance between reactive oxygen species (ROS) and antioxidants contributes to the pathogenesis of arthritis, cancer, cardiovascular, liver and respiratory diseases. Proinflammatory cytokines and growth factors stimulate ROS production as signaling mediators. Antiox...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2003-01, Vol.60 (1), p.6-20
Hauptverfasser:	Zafarullah, M, Li, W Q, Sylvester, J, Ahmad, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Antioxidants Antioxidants - pharmacology Apoptosis Cell Survival Cellular biology Detoxification Free Radical Scavengers - pharmacology Free radicals Growth factors Humans JNK Mitogen-Activated Protein Kinases Liver - drug effects Liver - metabolism Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Molecular biology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism NF-kappa B - drug effects NF-kappa B - metabolism Oxidation-Reduction Oxidative Stress p38 Mitogen-Activated Protein Kinases Proteins Reactive Oxygen Species - metabolism Respiratory diseases Review Signal Transduction
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