Aloe-emodin prevents cytokine-induced tumor cell death: the inhibition of auto-toxic nitric oxide release as a potential mechanism

Aloe-emodin (AE) is a plant-derived hydroxyanthraquinone with potential anticancer activity. We investigated the ability of AE to modulate survival of mouse L929 fibrosarcoma and rat C6 astrocytoma cells through interference with the activation of inducible nitric oxide (NO) synthase (NOS) and subse...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2004-07, Vol.61 (14), p.1805-1815
Hauptverfasser:	Mijatovic, S, Maksimovic-Ivanic, D, Radovic, J, Popadic, D, Momcilovic, M, Harhaji, L, Miljkovic, D, Trajkovic, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthraquinones Antitumor activity Apoptosis Apoptosis - drug effects Astrocytes - drug effects Cytokines - drug effects DNA-Binding Proteins - drug effects Down-Regulation Emodin - pharmacology Fibroblasts - drug effects Free radicals Interferon Regulatory Factor-1 Mice NF-kappa B - drug effects Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type II Phosphoproteins - drug effects Proteins Rats Rodents Tumor Cells, Cultured Tumors
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