Fatty acid metabolism in Saccharomyces cerevisiae
Peroxisomes are essential subcellular organelles involved in a variety of metabolic processes. Their importance is underlined by the identification of a large group of inherited diseases in humans in which one or more of the peroxisomal functions are impaired. The yeast Saccharomyces cerevisiae has...
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description | Peroxisomes are essential subcellular organelles involved in a variety of metabolic processes. Their importance is underlined by the identification of a large group of inherited diseases in humans in which one or more of the peroxisomal functions are impaired. The yeast Saccharomyces cerevisiae has been used as a model organism to study the functions of peroxisomes. Efficient oxidation of fatty acids does not only require the participation of peroxisomal enzymes but also the active involvement of other gene products. One group of important gene products in this respect includes peroxisomal membrane proteins involved in metabolite transport. This overview discusses the various aspects of fatty acid beta-oxidation in S. cerevisiae. Addressed are the various enzymes and their particular functions as well as the various transport mechanisms to take up fatty acids into peroxisomes or to export the beta-oxidation products out of the peroxisome to mitochondria for full oxidation to CO2 and H2O. |
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Their importance is underlined by the identification of a large group of inherited diseases in humans in which one or more of the peroxisomal functions are impaired. The yeast Saccharomyces cerevisiae has been used as a model organism to study the functions of peroxisomes. Efficient oxidation of fatty acids does not only require the participation of peroxisomal enzymes but also the active involvement of other gene products. One group of important gene products in this respect includes peroxisomal membrane proteins involved in metabolite transport. This overview discusses the various aspects of fatty acid beta-oxidation in S. cerevisiae. Addressed are the various enzymes and their particular functions as well as the various transport mechanisms to take up fatty acids into peroxisomes or to export the beta-oxidation products out of the peroxisome to mitochondria for full oxidation to CO2 and H2O.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-003-3076-x</identifier><identifier>PMID: 14523547</identifier><language>eng</language><publisher>Switzerland: Springer Nature B.V</publisher><subject>Adenosine Triphosphate - metabolism ; Biological Transport - physiology ; Fatty acids ; Fatty Acids - chemistry ; Fatty Acids - metabolism ; Genetics ; Humans ; Membrane Proteins - metabolism ; Metabolites ; Mitochondria - metabolism ; Molecular Structure ; Oxidation ; Oxidation-Reduction ; Peroxisomes - enzymology ; Peroxisomes - metabolism ; Proteins ; Review Paper ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Yeast ; Yeasts</subject><ispartof>Cellular and molecular life sciences : CMLS, 2003-09, Vol.60 (9), p.1838-1851</ispartof><rights>Birkhäuser-Verlag Basel 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-dc30085f2964282da821ac5e8be0200b6277f071060cefee8782f218223d98843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138760/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138760/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14523547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Roermund, C W T</creatorcontrib><creatorcontrib>Waterham, H R</creatorcontrib><creatorcontrib>Ijlst, L</creatorcontrib><creatorcontrib>Wanders, R J A</creatorcontrib><title>Fatty acid metabolism in Saccharomyces cerevisiae</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell Mol Life Sci</addtitle><description>Peroxisomes are essential subcellular organelles involved in a variety of metabolic processes. Their importance is underlined by the identification of a large group of inherited diseases in humans in which one or more of the peroxisomal functions are impaired. The yeast Saccharomyces cerevisiae has been used as a model organism to study the functions of peroxisomes. Efficient oxidation of fatty acids does not only require the participation of peroxisomal enzymes but also the active involvement of other gene products. One group of important gene products in this respect includes peroxisomal membrane proteins involved in metabolite transport. This overview discusses the various aspects of fatty acid beta-oxidation in S. cerevisiae. Addressed are the various enzymes and their particular functions as well as the various transport mechanisms to take up fatty acids into peroxisomes or to export the beta-oxidation products out of the peroxisome to mitochondria for full oxidation to CO2 and H2O.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Biological Transport - physiology</subject><subject>Fatty acids</subject><subject>Fatty Acids - chemistry</subject><subject>Fatty Acids - metabolism</subject><subject>Genetics</subject><subject>Humans</subject><subject>Membrane Proteins - metabolism</subject><subject>Metabolites</subject><subject>Mitochondria - metabolism</subject><subject>Molecular Structure</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Peroxisomes - enzymology</subject><subject>Peroxisomes - metabolism</subject><subject>Proteins</subject><subject>Review Paper</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - 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subjects | Adenosine Triphosphate - metabolism Biological Transport - physiology Fatty acids Fatty Acids - chemistry Fatty Acids - metabolism Genetics Humans Membrane Proteins - metabolism Metabolites Mitochondria - metabolism Molecular Structure Oxidation Oxidation-Reduction Peroxisomes - enzymology Peroxisomes - metabolism Proteins Review Paper Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Yeast Yeasts |
title | Fatty acid metabolism in Saccharomyces cerevisiae |
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