Epicardial adipose tissue as a prognostic marker in acute pulmonary embolism
Background Epicardial adipose tissue (EAT) has been established as a quantitative imaging biomarker associated with disease severity in coronary heart disease. Our aim was to use this prognostic marker derived from computed tomography pulmonary angiography (CTPA) for the prediction of mortality and...
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| Veröffentlicht in: | Herz 2024-06, Vol.49 (3), p.219-223 |
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| description | Background
Epicardial adipose tissue (EAT) has been established as a quantitative imaging biomarker associated with disease severity in coronary heart disease. Our aim was to use this prognostic marker derived from computed tomography pulmonary angiography (CTPA) for the prediction of mortality and prognosis in patients with acute pulmonary embolism.
Methods
The clinical database was retrospectively screened for patients with acute pulmonary embolism between 2015 and 2021. Overall, 513 patients (216 female, 42.1%) were included in the analysis. The study end-point was 30-day mortality. Epicardial adipose tissue was measured on the diagnostic CTPA in a semiquantitative manner. The volume and density of EAT were measured for every patient.
Results
Overall, 60 patients (10.4%) died within the 30-day observation period. The mean EAT volume was 128.3 ± 65.0 cm
3
in survivors and 154.6 ± 84.5 cm
3
in nonsurvivors (
p
= 0.02). The density of EAT was −79.4 ± 8.3 HU in survivors and −76.0 ± 8.4 HU in nonsurvivors (
p
= 0.86), and EAT density was associated with 30-day mortality (odds ratio [OR] = 1.07; 95% confidence interval [CI]: 1.03; 1.1,
p
|
| doi_str_mv | 10.1007/s00059-023-05210-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11136740</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3061503925</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-b32b885a3c645131d59849f2cfbf7da93963b303bfa31d9e895acc2c50959e7f3</originalsourceid><addsrcrecordid>eNp9kc1O3DAUha2qqAy0L8ACWWLDJuXaN07iVVWNaKk0iA1dW47jDB6SONgJEm_Ds_TJMAylwKKruzjfPffnEHLA4CsDKE8iAAiZAccMBGeQiQ9kwQomsqKQ_CNZAOaQSYnlLtmLcQPAhOTwiexiWeUlsmJBzk9HZ3RonO6obtzoo6WTi3G2VEeq_9yPwa8HHydnaK_DtQ3UDVSbebJ0nLveDzrcUdvXvnOx_0x2Wt1F--W57pPfP04vl2fZ6uLnr-X3VWZyZFNWI6-rSmg0RS4YskbIKpctN23dlo2WKAusEbBudRKlraTQxnAjQAppyxb3ybet7zjXvW2MHaagOzUGl3a8U1479VYZ3JVa-1vFGMOizCE5HD87BH8z2zip3kVju04P1s9R8aqsuOTIeUKP3qEbP4ch3acQ0rcBJReJ4lvKBB9jsO3LNgzUY1xqG5dKcamnuNRj0-HrO15a_uaTANwCMUnD2oZ_s_9j-wCg6qGz</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3061503925</pqid></control><display><type>article</type><title>Epicardial adipose tissue as a prognostic marker in acute pulmonary embolism</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Aghayev, Anar ; Hinnerichs, Mattes ; Wienke, Andreas ; Meyer, Hans-Jonas ; Surov, Alexey</creator><creatorcontrib>Aghayev, Anar ; Hinnerichs, Mattes ; Wienke, Andreas ; Meyer, Hans-Jonas ; Surov, Alexey</creatorcontrib><description>Background
Epicardial adipose tissue (EAT) has been established as a quantitative imaging biomarker associated with disease severity in coronary heart disease. Our aim was to use this prognostic marker derived from computed tomography pulmonary angiography (CTPA) for the prediction of mortality and prognosis in patients with acute pulmonary embolism.
Methods
The clinical database was retrospectively screened for patients with acute pulmonary embolism between 2015 and 2021. Overall, 513 patients (216 female, 42.1%) were included in the analysis. The study end-point was 30-day mortality. Epicardial adipose tissue was measured on the diagnostic CTPA in a semiquantitative manner. The volume and density of EAT were measured for every patient.
Results
Overall, 60 patients (10.4%) died within the 30-day observation period. The mean EAT volume was 128.3 ± 65.0 cm
3
in survivors and 154.6 ± 84.5 cm
3
in nonsurvivors (
p
= 0.02). The density of EAT was −79.4 ± 8.3 HU in survivors and −76.0 ± 8.4 HU in nonsurvivors (
p
= 0.86), and EAT density was associated with 30-day mortality (odds ratio [OR] = 1.07; 95% confidence interval [CI]: 1.03; 1.1,
p
< 0.001) but did not remain statistically significant in multivariable analysis. No association was identified between EAT volume and 30-day mortality (OR = 1.0; 95% CI: 1.0; 1.0,
p
= 0.48).
Conclusion
There might be an association between EAT density and mortality in patients with acute pulmonary embolism. Further studies are needed to elucidate the prognostic relevance of EAT parameters in patients with acute pulmonary embolism.</description><identifier>ISSN: 0340-9937</identifier><identifier>ISSN: 1615-6692</identifier><identifier>EISSN: 1615-6692</identifier><identifier>DOI: 10.1007/s00059-023-05210-5</identifier><identifier>PMID: 37847316</identifier><language>eng</language><publisher>Heidelberg: Springer Medizin</publisher><subject>Acute Disease ; Adipose tissue ; Adipose Tissue - diagnostic imaging ; Aged ; Angiography ; Biomarkers ; Body fat ; Cardiology ; Cardiovascular disease ; Cardiovascular diseases ; Computed tomography ; Computed Tomography Angiography - methods ; Coronary artery disease ; Density ; Embolism ; Embolisms ; Epicardial Adipose Tissue ; Female ; Heart diseases ; Humans ; Internal Medicine ; Lungs ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Original ; Original Articles ; Parameters ; Pericardium - diagnostic imaging ; Prognosis ; Pulmonary Embolism - diagnostic imaging ; Pulmonary Embolism - mortality ; Pulmonary embolisms ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Statistical analysis ; Survival Rate</subject><ispartof>Herz, 2024-06, Vol.49 (3), p.219-223</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-b32b885a3c645131d59849f2cfbf7da93963b303bfa31d9e895acc2c50959e7f3</citedby><cites>FETCH-LOGICAL-c431t-b32b885a3c645131d59849f2cfbf7da93963b303bfa31d9e895acc2c50959e7f3</cites><orcidid>0000-0001-8489-706X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00059-023-05210-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00059-023-05210-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37847316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aghayev, Anar</creatorcontrib><creatorcontrib>Hinnerichs, Mattes</creatorcontrib><creatorcontrib>Wienke, Andreas</creatorcontrib><creatorcontrib>Meyer, Hans-Jonas</creatorcontrib><creatorcontrib>Surov, Alexey</creatorcontrib><title>Epicardial adipose tissue as a prognostic marker in acute pulmonary embolism</title><title>Herz</title><addtitle>Herz</addtitle><addtitle>Herz</addtitle><description>Background
Epicardial adipose tissue (EAT) has been established as a quantitative imaging biomarker associated with disease severity in coronary heart disease. Our aim was to use this prognostic marker derived from computed tomography pulmonary angiography (CTPA) for the prediction of mortality and prognosis in patients with acute pulmonary embolism.
Methods
The clinical database was retrospectively screened for patients with acute pulmonary embolism between 2015 and 2021. Overall, 513 patients (216 female, 42.1%) were included in the analysis. The study end-point was 30-day mortality. Epicardial adipose tissue was measured on the diagnostic CTPA in a semiquantitative manner. The volume and density of EAT were measured for every patient.
Results
Overall, 60 patients (10.4%) died within the 30-day observation period. The mean EAT volume was 128.3 ± 65.0 cm
3
in survivors and 154.6 ± 84.5 cm
3
in nonsurvivors (
p
= 0.02). The density of EAT was −79.4 ± 8.3 HU in survivors and −76.0 ± 8.4 HU in nonsurvivors (
p
= 0.86), and EAT density was associated with 30-day mortality (odds ratio [OR] = 1.07; 95% confidence interval [CI]: 1.03; 1.1,
p
< 0.001) but did not remain statistically significant in multivariable analysis. No association was identified between EAT volume and 30-day mortality (OR = 1.0; 95% CI: 1.0; 1.0,
p
= 0.48).
Conclusion
There might be an association between EAT density and mortality in patients with acute pulmonary embolism. Further studies are needed to elucidate the prognostic relevance of EAT parameters in patients with acute pulmonary embolism.</description><subject>Acute Disease</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Aged</subject><subject>Angiography</subject><subject>Biomarkers</subject><subject>Body fat</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Computed tomography</subject><subject>Computed Tomography Angiography - methods</subject><subject>Coronary artery disease</subject><subject>Density</subject><subject>Embolism</subject><subject>Embolisms</subject><subject>Epicardial Adipose Tissue</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lungs</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Original</subject><subject>Original Articles</subject><subject>Parameters</subject><subject>Pericardium - diagnostic imaging</subject><subject>Prognosis</subject><subject>Pulmonary Embolism - diagnostic imaging</subject><subject>Pulmonary Embolism - mortality</subject><subject>Pulmonary embolisms</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Statistical analysis</subject><subject>Survival Rate</subject><issn>0340-9937</issn><issn>1615-6692</issn><issn>1615-6692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1O3DAUha2qqAy0L8ACWWLDJuXaN07iVVWNaKk0iA1dW47jDB6SONgJEm_Ds_TJMAylwKKruzjfPffnEHLA4CsDKE8iAAiZAccMBGeQiQ9kwQomsqKQ_CNZAOaQSYnlLtmLcQPAhOTwiexiWeUlsmJBzk9HZ3RonO6obtzoo6WTi3G2VEeq_9yPwa8HHydnaK_DtQ3UDVSbebJ0nLveDzrcUdvXvnOx_0x2Wt1F--W57pPfP04vl2fZ6uLnr-X3VWZyZFNWI6-rSmg0RS4YskbIKpctN23dlo2WKAusEbBudRKlraTQxnAjQAppyxb3ybet7zjXvW2MHaagOzUGl3a8U1479VYZ3JVa-1vFGMOizCE5HD87BH8z2zip3kVju04P1s9R8aqsuOTIeUKP3qEbP4ch3acQ0rcBJReJ4lvKBB9jsO3LNgzUY1xqG5dKcamnuNRj0-HrO15a_uaTANwCMUnD2oZ_s_9j-wCg6qGz</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Aghayev, Anar</creator><creator>Hinnerichs, Mattes</creator><creator>Wienke, Andreas</creator><creator>Meyer, Hans-Jonas</creator><creator>Surov, Alexey</creator><general>Springer Medizin</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8489-706X</orcidid></search><sort><creationdate>20240601</creationdate><title>Epicardial adipose tissue as a prognostic marker in acute pulmonary embolism</title><author>Aghayev, Anar ; Hinnerichs, Mattes ; Wienke, Andreas ; Meyer, Hans-Jonas ; Surov, Alexey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-b32b885a3c645131d59849f2cfbf7da93963b303bfa31d9e895acc2c50959e7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute Disease</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Aged</topic><topic>Angiography</topic><topic>Biomarkers</topic><topic>Body fat</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Computed tomography</topic><topic>Computed Tomography Angiography - methods</topic><topic>Coronary artery disease</topic><topic>Density</topic><topic>Embolism</topic><topic>Embolisms</topic><topic>Epicardial Adipose Tissue</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lungs</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Original</topic><topic>Original Articles</topic><topic>Parameters</topic><topic>Pericardium - diagnostic imaging</topic><topic>Prognosis</topic><topic>Pulmonary Embolism - diagnostic imaging</topic><topic>Pulmonary Embolism - mortality</topic><topic>Pulmonary embolisms</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Statistical analysis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aghayev, Anar</creatorcontrib><creatorcontrib>Hinnerichs, Mattes</creatorcontrib><creatorcontrib>Wienke, Andreas</creatorcontrib><creatorcontrib>Meyer, Hans-Jonas</creatorcontrib><creatorcontrib>Surov, Alexey</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Herz</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aghayev, Anar</au><au>Hinnerichs, Mattes</au><au>Wienke, Andreas</au><au>Meyer, Hans-Jonas</au><au>Surov, Alexey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epicardial adipose tissue as a prognostic marker in acute pulmonary embolism</atitle><jtitle>Herz</jtitle><stitle>Herz</stitle><addtitle>Herz</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>49</volume><issue>3</issue><spage>219</spage><epage>223</epage><pages>219-223</pages><issn>0340-9937</issn><issn>1615-6692</issn><eissn>1615-6692</eissn><abstract>Background
Epicardial adipose tissue (EAT) has been established as a quantitative imaging biomarker associated with disease severity in coronary heart disease. Our aim was to use this prognostic marker derived from computed tomography pulmonary angiography (CTPA) for the prediction of mortality and prognosis in patients with acute pulmonary embolism.
Methods
The clinical database was retrospectively screened for patients with acute pulmonary embolism between 2015 and 2021. Overall, 513 patients (216 female, 42.1%) were included in the analysis. The study end-point was 30-day mortality. Epicardial adipose tissue was measured on the diagnostic CTPA in a semiquantitative manner. The volume and density of EAT were measured for every patient.
Results
Overall, 60 patients (10.4%) died within the 30-day observation period. The mean EAT volume was 128.3 ± 65.0 cm
3
in survivors and 154.6 ± 84.5 cm
3
in nonsurvivors (
p
= 0.02). The density of EAT was −79.4 ± 8.3 HU in survivors and −76.0 ± 8.4 HU in nonsurvivors (
p
= 0.86), and EAT density was associated with 30-day mortality (odds ratio [OR] = 1.07; 95% confidence interval [CI]: 1.03; 1.1,
p
< 0.001) but did not remain statistically significant in multivariable analysis. No association was identified between EAT volume and 30-day mortality (OR = 1.0; 95% CI: 1.0; 1.0,
p
= 0.48).
Conclusion
There might be an association between EAT density and mortality in patients with acute pulmonary embolism. Further studies are needed to elucidate the prognostic relevance of EAT parameters in patients with acute pulmonary embolism.</abstract><cop>Heidelberg</cop><pub>Springer Medizin</pub><pmid>37847316</pmid><doi>10.1007/s00059-023-05210-5</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8489-706X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acute Disease Adipose tissue Adipose Tissue - diagnostic imaging Aged Angiography Biomarkers Body fat Cardiology Cardiovascular disease Cardiovascular diseases Computed tomography Computed Tomography Angiography - methods Coronary artery disease Density Embolism Embolisms Epicardial Adipose Tissue Female Heart diseases Humans Internal Medicine Lungs Male Medicine Medicine & Public Health Middle Aged Mortality Original Original Articles Parameters Pericardium - diagnostic imaging Prognosis Pulmonary Embolism - diagnostic imaging Pulmonary Embolism - mortality Pulmonary embolisms Reproducibility of Results Retrospective Studies Sensitivity and Specificity Statistical analysis Survival Rate |
| title | Epicardial adipose tissue as a prognostic marker in acute pulmonary embolism |
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