Human beta-defensins

The last decade led to the discovery and characterization of several human beta-defensins. Analysis of genomic information indicates that the number of beta-defensin-like molecules encoded by the human genome may number in the tens. Growing interest in beta-defensins steadily enhances our knowledge...

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Veröffentlicht in:Cellular and molecular life sciences : CMLS 2006-06, Vol.63 (11), p.1294-1313
Hauptverfasser: Pazgier, M, Hoover, D M, Yang, D, Lu, W, Lubkowski, J
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container_issue 11
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container_title Cellular and molecular life sciences : CMLS
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creator Pazgier, M
Hoover, D M
Yang, D
Lu, W
Lubkowski, J
description The last decade led to the discovery and characterization of several human beta-defensins. Analysis of genomic information indicates that the number of beta-defensin-like molecules encoded by the human genome may number in the tens. Growing interest in beta-defensins steadily enhances our knowledge about various aspects of their gene location, expression patterns and the transcription factors involved in their regulation in vivo. The hallmark property of beta-defensins, their antimicrobial activity, is clearly only the tip of the iceberg in the extensive network of inter-relations within the immune system in which these peptides function. Structural studies of beta-defensins provide the molecular basis for a better understanding of their properties, functions and their potential for practical applications. In this review, we present some recent advances in the studies of human beta-defensins, with an emphasis on possible correlations between their structural and functional properties.
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subjects Amino Acid Sequence
Anti-Infective Agents - pharmacology
Antimicrobial Cationic Peptides - pharmacology
beta-Defensins - chemistry
beta-Defensins - classification
beta-Defensins - genetics
beta-Defensins - immunology
beta-Defensins - pharmacology
Humans
Models, Molecular
Molecular Sequence Data
Protein Structure, Quaternary
Protein Structure, Tertiary
Review
Sequence Homology, Amino Acid
Structure-Activity Relationship
title Human beta-defensins
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