Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation
Lipid metabolism is important for the maintenance of physiological homeostasis. Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid homeostasis. However, the function of Senp7 in lipid metabolism remains unclear. I...
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| Veröffentlicht in: | The Journal of biological chemistry 2024-06, Vol.300 (6), p.107319, Article 107319 |
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| creator | Pei, Jingwen Zou, Dayuan Li, Lu Kang, Lulu Sun, Minli Li, Xu Chen, Qianyue Chen, Danning Qu, Bin Gao, Xiang Lin, Zhaoyu |
| description | Lipid metabolism is important for the maintenance of physiological homeostasis. Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid homeostasis. However, the function of Senp7 in lipid metabolism remains unclear. In this study, we generated both conventional and adipocyte-specific Senp7 KO mice to characterize the role of Senp7 in lipid metabolism homeostasis. Both Senp7-deficient mice displayed reduced white adipose tissue mass and decreased size of adipocytes. By analyzing the lipid droplet morphology, we demonstrated that the lipid droplet size was significantly smaller in Senp7-deficient adipocytes. Mechanistically, Senp7 could deSUMOylate the perilipin family protein Plin4 to promote the lipid droplet localization of Plin4. Our results reveal an important role of Senp7 in the maturation of lipid droplets via Plin4 deSUMOylation. |
| doi_str_mv | 10.1016/j.jbc.2024.107319 |
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Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid homeostasis. However, the function of Senp7 in lipid metabolism remains unclear. In this study, we generated both conventional and adipocyte-specific Senp7 KO mice to characterize the role of Senp7 in lipid metabolism homeostasis. Both Senp7-deficient mice displayed reduced white adipose tissue mass and decreased size of adipocytes. By analyzing the lipid droplet morphology, we demonstrated that the lipid droplet size was significantly smaller in Senp7-deficient adipocytes. Mechanistically, Senp7 could deSUMOylate the perilipin family protein Plin4 to promote the lipid droplet localization of Plin4. Our results reveal an important role of Senp7 in the maturation of lipid droplets via Plin4 deSUMOylation.</description><identifier>ISSN: 0021-9258</identifier><identifier>ISSN: 1083-351X</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/j.jbc.2024.107319</identifier><identifier>PMID: 38677512</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>deSUMOylation ; lipid droplet ; lipid storage ; Plin4 ; Senp7</subject><ispartof>The Journal of biological chemistry, 2024-06, Vol.300 (6), p.107319, Article 107319</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Inc. 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Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid homeostasis. However, the function of Senp7 in lipid metabolism remains unclear. In this study, we generated both conventional and adipocyte-specific Senp7 KO mice to characterize the role of Senp7 in lipid metabolism homeostasis. Both Senp7-deficient mice displayed reduced white adipose tissue mass and decreased size of adipocytes. By analyzing the lipid droplet morphology, we demonstrated that the lipid droplet size was significantly smaller in Senp7-deficient adipocytes. Mechanistically, Senp7 could deSUMOylate the perilipin family protein Plin4 to promote the lipid droplet localization of Plin4. Our results reveal an important role of Senp7 in the maturation of lipid droplets via Plin4 deSUMOylation.</description><subject>deSUMOylation</subject><subject>lipid droplet</subject><subject>lipid storage</subject><subject>Plin4</subject><subject>Senp7</subject><issn>0021-9258</issn><issn>1083-351X</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kU9vEzEQxS0EoqHwAbggH7ls8P9diwNCVSlIrVqprcTNcmwvnWh3vdhOUL59naZU9IIvI8vvvfHMD6H3lCwpoerTerleuSUjTNR7y6l-gRaUdLzhkv58iRaEMNpoJrsj9CbnNalHaPoaHfFOta2kbIHcdZjmFvvQg4MwuR2GcbaQMh5gBo99ivMQSsajLZtkC8QJw4T_3EEJ2HqYYw64QM6bkPEWLL4aYBI17_r24nI3PBjeole9HXJ491iP0e2305uT78355dmPk6_njROSlUZ6YbVyHSNWERlWzDGlmXO-64noKJGdUqzVXvQt0VI54fx-6t5zpqhbtfwYfTnkzpvVGLwLU0l2MHOC0aadiRbM85cJ7syvuDWUUi6kFDXh42NCir_rRMWMkF0YBjuFuMmGE9Fq0RHNq5QepC7FnFPon_pQYvZ0zNpUOmZPxxzoVM-Hfz_45PiLowo-HwShrmkLIZn8QCV4SMEV4yP8J_4evfyhDA</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Pei, Jingwen</creator><creator>Zou, Dayuan</creator><creator>Li, Lu</creator><creator>Kang, Lulu</creator><creator>Sun, Minli</creator><creator>Li, Xu</creator><creator>Chen, Qianyue</creator><creator>Chen, Danning</creator><creator>Qu, Bin</creator><creator>Gao, Xiang</creator><creator>Lin, Zhaoyu</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9382-3203</orcidid></search><sort><creationdate>20240601</creationdate><title>Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation</title><author>Pei, Jingwen ; Zou, Dayuan ; Li, Lu ; Kang, Lulu ; Sun, Minli ; Li, Xu ; Chen, Qianyue ; Chen, Danning ; Qu, Bin ; Gao, Xiang ; Lin, Zhaoyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-5d4a96c820a605eb2c2692ccd8f048105866279d4f70956c4cd1073fd3261cb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>deSUMOylation</topic><topic>lipid droplet</topic><topic>lipid storage</topic><topic>Plin4</topic><topic>Senp7</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pei, Jingwen</creatorcontrib><creatorcontrib>Zou, Dayuan</creatorcontrib><creatorcontrib>Li, Lu</creatorcontrib><creatorcontrib>Kang, Lulu</creatorcontrib><creatorcontrib>Sun, Minli</creatorcontrib><creatorcontrib>Li, Xu</creatorcontrib><creatorcontrib>Chen, Qianyue</creatorcontrib><creatorcontrib>Chen, Danning</creatorcontrib><creatorcontrib>Qu, Bin</creatorcontrib><creatorcontrib>Gao, Xiang</creatorcontrib><creatorcontrib>Lin, Zhaoyu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pei, Jingwen</au><au>Zou, Dayuan</au><au>Li, Lu</au><au>Kang, Lulu</au><au>Sun, Minli</au><au>Li, Xu</au><au>Chen, Qianyue</au><au>Chen, Danning</au><au>Qu, Bin</au><au>Gao, Xiang</au><au>Lin, Zhaoyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>300</volume><issue>6</issue><spage>107319</spage><pages>107319-</pages><artnum>107319</artnum><issn>0021-9258</issn><issn>1083-351X</issn><eissn>1083-351X</eissn><abstract>Lipid metabolism is important for the maintenance of physiological homeostasis. Several members of the small ubiquitin-like modifier (SUMO)-specific protease (SENP) family have been reported as the regulators of lipid homeostasis. However, the function of Senp7 in lipid metabolism remains unclear. In this study, we generated both conventional and adipocyte-specific Senp7 KO mice to characterize the role of Senp7 in lipid metabolism homeostasis. Both Senp7-deficient mice displayed reduced white adipose tissue mass and decreased size of adipocytes. By analyzing the lipid droplet morphology, we demonstrated that the lipid droplet size was significantly smaller in Senp7-deficient adipocytes. Mechanistically, Senp7 could deSUMOylate the perilipin family protein Plin4 to promote the lipid droplet localization of Plin4. 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| subjects | deSUMOylation lipid droplet lipid storage Plin4 Senp7 |
| title | Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation |
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