Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin

This review discusses the state-of-the-art in molecular research on the most prominent and widely applied lantibiotic, i.e., nisin. The developments in understanding its complex biosynthesis and mode of action are highlighted. Moreover, novel applications arising from engineering either nisin itself...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2008-02, Vol.65 (3), p.455-476
Hauptverfasser:	Lubelski, J, Rink, R, Khusainov, R, Moll, G. N, Kuipers, O. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibiotics Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriocins - chemistry Bacteriocins - immunology Bacteriocins - metabolism Biochemistry Bioengineering Biomedical and Life Sciences Biomedicine Biosynthesis Cell Biology cyclization Dehydration Hydro-Lyases - chemistry Hydro-Lyases - metabolism Life Sciences mechanism of action Mode of action Models, Molecular Molecular biology Molecular Sequence Data Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism nisin Nisin - chemistry Nisin - immunology Nisin - metabolism Peptides Protein Conformation protein engineering Protein Processing, Post-Translational Proteins Review Sequence Alignment Substrate Specificity therapeutical peptides thioether-containing peptides
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