Proteinases in cutaneous wound healing
Cutaneous wound healing is a complex and highly coordinated process where a number of different cell types participate to renew the damaged tissue under the strict regulation of soluble and insoluble factors. One of the most versatile processes involved in wound repair is proteolysis. During cell mi...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2009-01, Vol.66 (2), p.203-224 |
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| creator | Toriseva, M Kähäri, V.-M |
| description | Cutaneous wound healing is a complex and highly coordinated process where a number of different cell types participate to renew the damaged tissue under the strict regulation of soluble and insoluble factors. One of the most versatile processes involved in wound repair is proteolysis. During cell migration, proteins of extracellular matrix are cleaved, often creating biologically active cleavage products, and proteolysis of cellular contacts leads to increased cell motility and division. Moreover, proteases activate various growth factors and other proteases in wound and regulate growth factor signaling by shedding growth factor receptors on cell surface. Normally, proteolysis is strictly controlled, and changes in protease activity are associated with alterations in wound closure and scar formation. Here, we present the current view on the role of metalloproteinases and the plasmin-plasminogen system in normal and aberrant cutaneous wound repair and discuss their role as potential therapeutic targets for chronic ulcers or fibrotic scars. |
| doi_str_mv | 10.1007/s00018-008-8388-4 |
| format | Article |
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One of the most versatile processes involved in wound repair is proteolysis. During cell migration, proteins of extracellular matrix are cleaved, often creating biologically active cleavage products, and proteolysis of cellular contacts leads to increased cell motility and division. Moreover, proteases activate various growth factors and other proteases in wound and regulate growth factor signaling by shedding growth factor receptors on cell surface. Normally, proteolysis is strictly controlled, and changes in protease activity are associated with alterations in wound closure and scar formation. Here, we present the current view on the role of metalloproteinases and the plasmin-plasminogen system in normal and aberrant cutaneous wound repair and discuss their role as potential therapeutic targets for chronic ulcers or fibrotic scars.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-008-8388-4</identifier><identifier>PMID: 18810321</identifier><language>eng</language><publisher>Basel: Basel : Birkhäuser-Verlag</publisher><subject>ADAM ; ADAM Proteins - metabolism ; ADAMTS ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell adhesion & migration ; Cell Biology ; Cicatrix - metabolism ; Cicatrix - pathology ; Fibrinolysin - metabolism ; fibrosis ; Growth factors ; Humans ; Life Sciences ; Matrix Metalloproteinases - metabolism ; MMP ; Models, Biological ; Peptide Hydrolases - metabolism ; plasminogen ; Proteins ; Review ; skin ; Skin - injuries ; Skin - metabolism ; Tissue Inhibitor of Metalloproteinases - metabolism ; wound ; Wound healing ; Wound Healing - physiology</subject><ispartof>Cellular and molecular life sciences : CMLS, 2009-01, Vol.66 (2), p.203-224</ispartof><rights>Birkhäuser Verlag, Basel 2008</rights><rights>Birkhäuser Verlag, Basel 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-5019bc7fc259754c589f03521522c86bd3a0bddbeb4b1b5be0904ec637ee07803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131559/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131559/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18810321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toriseva, M</creatorcontrib><creatorcontrib>Kähäri, V.-M</creatorcontrib><title>Proteinases in cutaneous wound healing</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Cutaneous wound healing is a complex and highly coordinated process where a number of different cell types participate to renew the damaged tissue under the strict regulation of soluble and insoluble factors. One of the most versatile processes involved in wound repair is proteolysis. During cell migration, proteins of extracellular matrix are cleaved, often creating biologically active cleavage products, and proteolysis of cellular contacts leads to increased cell motility and division. Moreover, proteases activate various growth factors and other proteases in wound and regulate growth factor signaling by shedding growth factor receptors on cell surface. Normally, proteolysis is strictly controlled, and changes in protease activity are associated with alterations in wound closure and scar formation. Here, we present the current view on the role of metalloproteinases and the plasmin-plasminogen system in normal and aberrant cutaneous wound repair and discuss their role as potential therapeutic targets for chronic ulcers or fibrotic scars.</description><subject>ADAM</subject><subject>ADAM Proteins - metabolism</subject><subject>ADAMTS</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell adhesion & migration</subject><subject>Cell Biology</subject><subject>Cicatrix - metabolism</subject><subject>Cicatrix - pathology</subject><subject>Fibrinolysin - metabolism</subject><subject>fibrosis</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>MMP</subject><subject>Models, Biological</subject><subject>Peptide Hydrolases - metabolism</subject><subject>plasminogen</subject><subject>Proteins</subject><subject>Review</subject><subject>skin</subject><subject>Skin - injuries</subject><subject>Skin - metabolism</subject><subject>Tissue Inhibitor of Metalloproteinases - metabolism</subject><subject>wound</subject><subject>Wound healing</subject><subject>Wound Healing - physiology</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1L5TAUxYM4-P0HuNGHC3cd702aj65EZNQBQUEFdyFJ02elL9GkVea_nz76UGcWrhK4v3NyTw4h-wg_EUCeZABAVQCoQjGlinKNbGFJoahA4vrqLhR93CTbOT-PMFdUbJBNVAqBUdwix7cp9r4NJvs8a8PMDb0JPg559h6HUM-evOnaMN8lPxrTZb-3OnfIw8Wv-_Or4vrm8vf52XXhyrLqCw5YWScbR3kleem4qhpgnCKn1Clha2bA1rX1trRoufVQQemdYNJ7kArYDjmdfF8Gu_C186FPptMvqV2Y9EdH0-p_J6F90vP4phGRIefV6HC8ckjxdfC514s2O991UywthJJIJRvBo__A5zikMKbTUiBIJugSwglyKeacfPOxCoJedqCnDvTYgV52oMtRc_A1w6di9ekjQCcgj6Mw9-nz5e9cDydRY6I289Rm_XBHAdmyVCkFZ38BVeyaLQ</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Toriseva, M</creator><creator>Kähäri, V.-M</creator><general>Basel : Birkhäuser-Verlag</general><general>Birkhäuser-Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090101</creationdate><title>Proteinases in cutaneous wound healing</title><author>Toriseva, M ; Kähäri, V.-M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-5019bc7fc259754c589f03521522c86bd3a0bddbeb4b1b5be0904ec637ee07803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>ADAM</topic><topic>ADAM Proteins - metabolism</topic><topic>ADAMTS</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell adhesion & migration</topic><topic>Cell Biology</topic><topic>Cicatrix - metabolism</topic><topic>Cicatrix - pathology</topic><topic>Fibrinolysin - metabolism</topic><topic>fibrosis</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>MMP</topic><topic>Models, Biological</topic><topic>Peptide Hydrolases - metabolism</topic><topic>plasminogen</topic><topic>Proteins</topic><topic>Review</topic><topic>skin</topic><topic>Skin - injuries</topic><topic>Skin - metabolism</topic><topic>Tissue Inhibitor of Metalloproteinases - metabolism</topic><topic>wound</topic><topic>Wound healing</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toriseva, M</creatorcontrib><creatorcontrib>Kähäri, V.-M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>66</volume><issue>2</issue><spage>203</spage><epage>224</epage><pages>203-224</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Cutaneous wound healing is a complex and highly coordinated process where a number of different cell types participate to renew the damaged tissue under the strict regulation of soluble and insoluble factors. One of the most versatile processes involved in wound repair is proteolysis. During cell migration, proteins of extracellular matrix are cleaved, often creating biologically active cleavage products, and proteolysis of cellular contacts leads to increased cell motility and division. Moreover, proteases activate various growth factors and other proteases in wound and regulate growth factor signaling by shedding growth factor receptors on cell surface. Normally, proteolysis is strictly controlled, and changes in protease activity are associated with alterations in wound closure and scar formation. Here, we present the current view on the role of metalloproteinases and the plasmin-plasminogen system in normal and aberrant cutaneous wound repair and discuss their role as potential therapeutic targets for chronic ulcers or fibrotic scars.</abstract><cop>Basel</cop><pub>Basel : Birkhäuser-Verlag</pub><pmid>18810321</pmid><doi>10.1007/s00018-008-8388-4</doi><tpages>22</tpages></addata></record> |
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| identifier | ISSN: 1420-682X |
| ispartof | Cellular and molecular life sciences : CMLS, 2009-01, Vol.66 (2), p.203-224 |
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| subjects | ADAM ADAM Proteins - metabolism ADAMTS Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell adhesion & migration Cell Biology Cicatrix - metabolism Cicatrix - pathology Fibrinolysin - metabolism fibrosis Growth factors Humans Life Sciences Matrix Metalloproteinases - metabolism MMP Models, Biological Peptide Hydrolases - metabolism plasminogen Proteins Review skin Skin - injuries Skin - metabolism Tissue Inhibitor of Metalloproteinases - metabolism wound Wound healing Wound Healing - physiology |
| title | Proteinases in cutaneous wound healing |
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