Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly

The NLRP3 inflammasome is a cytosolic protein complex important for the regulation and secretion of inflammatory cytokines, including IL-1β and IL-18. Aberrant overactivation of NLRP3 is implicated in numerous inflammatory disorders. However, the activation and regulation of NLRP3 inflammasome signa...

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Veröffentlicht in:	ACS chemical biology 2024-02, Vol.19 (2), p.254-265
Hauptverfasser:	Stanton, Caroline, Sun, Jie, Nutsch, Kayla, Rosarda, Jessica D., Nguyen, Thu, Li-Ma, Chloris, Njomen, Evert, Melillo, Bruno, Kutseikin, Sergei, Saez, Enrique, Cravatt, Benjamin F., Teijaro, John R., Wiseman, R. Luke, Bollong, Michael J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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