Myxococcus xanthus encapsulin cargo protein EncD is a flavin-binding protein with ferric reductase activity

Encapsulins are protein nanocompartments that regulate cellular metabolism in several bacteria and archaea. encapsulins protect the bacterial cells against oxidative stress by sequestering cytosolic iron. These encapsulins are formed by the shell protein EncA and three cargo proteins: EncB, EncC, an...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-05, Vol.121 (21), p.e2400426121
Hauptverfasser:	Eren, Elif, Watts, Norman R, Conway, James F, Wingfield, Paul T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Bacteria Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biological Sciences Cargo Cryoelectron Microscopy Crystal structure Crystallography, X-Ray Dimers Encapsulation Ferroxidase Flavin mononucleotide Flavin Mononucleotide - metabolism FMN Reductase - metabolism Homeostasis Iron Iron - metabolism Metabolism Mineralization Models, Molecular Myxococcus xanthus Myxococcus xanthus - enzymology Myxococcus xanthus - metabolism Oxidative stress Protein turnover Proteins Reductases Sequestering Structure-function relationships
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