Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP

Ensartinib, an approved ALK inhibitor, is used as a first-line therapy for advanced ALK-positive non-small cell lung cancer in China. However, the hepatotoxicity of ensartinib seriously limits its clinical application and the regulatory mechanism is still elusive. Here, through transcriptome analysi...

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Veröffentlicht in:	Cell biology and toxicology 2024-05, Vol.40 (1), p.38, Article 38
Hauptverfasser:	Wu, Wentong, Li, Jinjin, Yin, Yiming, Zhou, Yourong, Huang, Xiangliang, Cao, Yashi, Chen, Xueqin, Zhou, Yunfang, Du, Jiangxia, Xu, Zhifei, Yang, Bo, He, Qiaojun, Yang, Xiaochun, Hu, Yuhuai, Yan, Hao, Luo, Peihua
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Antitumor activity Apoptosis Apoptosis - drug effects Attenuation Biochemistry Biomedical and Life Sciences Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control Flavonoids Gene regulation Hepatocytes - drug effects Hepatocytes - metabolism Hepatotoxicity Humans Inhibitors Life Sciences Liver - drug effects Liver - metabolism Liver - pathology Liver diseases Lung cancer Male Mice Mice, Inbred C57BL Non-small cell lung carcinoma Pharmacology/Toxicology Proteasomes Regulatory mechanisms (biology) Rutin Rutin - pharmacology Small cell lung carcinoma Transcription activation Transcriptomes Translocation
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