Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation

Background Altered patterns of bile acids (BAs) are frequently present in liver fibrosis, and BAs function as signaling molecules to initiate inflammatory responses. Therefore, this study was conducted to uncover the notably altered components of BAs and to explore the pathway of altered BA induced...

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Veröffentlicht in:	Hepatology international 2024-06, Vol.18 (3), p.1040-1052
Hauptverfasser:	Feng, Shu, Xie, Xingming, Li, Jianchao, Xu, Xu, Chen, Chaochun, Zou, Gaoliang, Lin, Guoyuan, Huang, Tao, Hu, Ruihan, Ran, Tao, Han, Lu, Zhang, Qingxiu, Li, Yuanqingxiao, Zhao, Xueke
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Assaying Bile Bile acids Bile Acids and Salts - metabolism Cell Line Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Collagen Colorectal Surgery Female Fibers Fibrosis Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatology Humans Inflammasomes Inflammasomes - metabolism Inflammation Liquid chromatography Liver Liver cirrhosis Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Male Mass spectrometry Mass spectroscopy Medicine Medicine & Public Health Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Original Original Article Phosphorylation Proteins Receptors, Cytoplasmic and Nuclear - metabolism Signal Transduction Surgery Western blotting Wound healing
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