Mammalian iron transport
Iron is essential for basic cellular processes but is toxic when present in excess. Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2009-10, Vol.66 (20), p.3241-3261 |
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| creator | Anderson, Gregory Jon Vulpe, Christopher D. |
| description | Iron is essential for basic cellular processes but is toxic when present in excess. Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins. Non-transferrin-bound iron can also be taken up efficiently by cells, although the mechanism is poorly understood. Cells can divest themselves of iron via the iron export protein ferroportin in conjunction with an iron oxidase. The linking of an oxidoreductase to a membrane permease is a common theme in membrane iron transport. At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma. |
| doi_str_mv | 10.1007/s00018-009-0051-1 |
| format | Article |
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Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins. Non-transferrin-bound iron can also be taken up efficiently by cells, although the mechanism is poorly understood. Cells can divest themselves of iron via the iron export protein ferroportin in conjunction with an iron oxidase. The linking of an oxidoreductase to a membrane permease is a common theme in membrane iron transport. At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-009-0051-1</identifier><identifier>PMID: 19484405</identifier><language>eng</language><publisher>Basel: SP Birkhäuser Verlag Basel</publisher><subject>Animals ; Antimicrobial Cationic Peptides - metabolism ; Antimicrobial Cationic Peptides - physiology ; Biochemistry ; Biological Transport ; Biomedical and Life Sciences ; Biomedicine ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Carrier Proteins - physiology ; Cell Biology ; Cellular biology ; Erythroid Cells - metabolism ; Gene Expression Regulation ; Hepatocytes - metabolism ; Hepatocytes - physiology ; Hepcidins ; Homeostasis ; Iron ; Iron - blood ; Iron - metabolism ; Life Sciences ; Macrophages - metabolism ; Macrophages - physiology ; Mammals ; Mammals - metabolism ; Membranes ; Mitochondria - metabolism ; Models, Biological ; Molecular biology ; Oxidoreductases - metabolism ; Oxidoreductases - physiology ; Review</subject><ispartof>Cellular and molecular life sciences : CMLS, 2009-10, Vol.66 (20), p.3241-3261</ispartof><rights>Birkhäuser Verlag, Basel/Switzerland 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-84732053a96c9d3ac7f9de353d6457040de5e16813e9113e94b1ddb8ee18df2e3</citedby><cites>FETCH-LOGICAL-c516t-84732053a96c9d3ac7f9de353d6457040de5e16813e9113e94b1ddb8ee18df2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115736/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115736/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19484405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Gregory Jon</creatorcontrib><creatorcontrib>Vulpe, Christopher D.</creatorcontrib><title>Mammalian iron transport</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Iron is essential for basic cellular processes but is toxic when present in excess. Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins. Non-transferrin-bound iron can also be taken up efficiently by cells, although the mechanism is poorly understood. Cells can divest themselves of iron via the iron export protein ferroportin in conjunction with an iron oxidase. The linking of an oxidoreductase to a membrane permease is a common theme in membrane iron transport. At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma.</description><subject>Animals</subject><subject>Antimicrobial Cationic Peptides - metabolism</subject><subject>Antimicrobial Cationic Peptides - physiology</subject><subject>Biochemistry</subject><subject>Biological Transport</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Carrier Proteins - physiology</subject><subject>Cell Biology</subject><subject>Cellular biology</subject><subject>Erythroid Cells - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Hepatocytes - metabolism</subject><subject>Hepatocytes - physiology</subject><subject>Hepcidins</subject><subject>Homeostasis</subject><subject>Iron</subject><subject>Iron - blood</subject><subject>Iron - metabolism</subject><subject>Life Sciences</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - physiology</subject><subject>Mammals</subject><subject>Mammals - metabolism</subject><subject>Membranes</subject><subject>Mitochondria - metabolism</subject><subject>Models, Biological</subject><subject>Molecular biology</subject><subject>Oxidoreductases - metabolism</subject><subject>Oxidoreductases - physiology</subject><subject>Review</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kM1LxDAQxYMo7rp614ss3qsz-WjTk8jiF6x4UfAWsk26dtk2a9IK_vdmaXH1YCCZwPzmzeMRcoZwiQDZVQAAlAlAHq_ABPfIGDmFJIcM94d_KunbiByFsIqwkDQ9JCPMueQcxJicPum61utKN9PKu2baet2EjfPtMTko9TrYk6FOyOvd7cvsIZk_3z_ObuZJITBtE8kzRkEwnadFbpgusjI3lglmUi4y4GCssJhKZDbH7cMXaMxCWovSlNSyCbnudTfdoramsE20sFYbX9XafymnK_W301Tvauk-FcYjMpZGhYtBwbuPzoZWrVznm2haUWQiUpRFCHuo8C4Eb8ufDQhqG6bqw1QxTLUNU2GcOf9tbTcxpBcB2gMhtpql9bvN_6t-A4gbfhA</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Anderson, Gregory Jon</creator><creator>Vulpe, Christopher D.</creator><general>SP Birkhäuser Verlag Basel</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20091001</creationdate><title>Mammalian iron transport</title><author>Anderson, Gregory Jon ; Vulpe, Christopher D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-84732053a96c9d3ac7f9de353d6457040de5e16813e9113e94b1ddb8ee18df2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Antimicrobial Cationic Peptides - metabolism</topic><topic>Antimicrobial Cationic Peptides - physiology</topic><topic>Biochemistry</topic><topic>Biological Transport</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Carrier Proteins - physiology</topic><topic>Cell Biology</topic><topic>Cellular biology</topic><topic>Erythroid Cells - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Hepatocytes - metabolism</topic><topic>Hepatocytes - physiology</topic><topic>Hepcidins</topic><topic>Homeostasis</topic><topic>Iron</topic><topic>Iron - blood</topic><topic>Iron - metabolism</topic><topic>Life Sciences</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - physiology</topic><topic>Mammals</topic><topic>Mammals - metabolism</topic><topic>Membranes</topic><topic>Mitochondria - metabolism</topic><topic>Models, Biological</topic><topic>Molecular biology</topic><topic>Oxidoreductases - metabolism</topic><topic>Oxidoreductases - physiology</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Gregory Jon</creatorcontrib><creatorcontrib>Vulpe, Christopher D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Gregory Jon</au><au>Vulpe, Christopher D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mammalian iron transport</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>66</volume><issue>20</issue><spage>3241</spage><epage>3261</epage><pages>3241-3261</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Iron is essential for basic cellular processes but is toxic when present in excess. Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins. Non-transferrin-bound iron can also be taken up efficiently by cells, although the mechanism is poorly understood. Cells can divest themselves of iron via the iron export protein ferroportin in conjunction with an iron oxidase. The linking of an oxidoreductase to a membrane permease is a common theme in membrane iron transport. At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma.</abstract><cop>Basel</cop><pub>SP Birkhäuser Verlag Basel</pub><pmid>19484405</pmid><doi>10.1007/s00018-009-0051-1</doi><tpages>21</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular and molecular life sciences : CMLS, 2009-10, Vol.66 (20), p.3241-3261 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Animals Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - physiology Biochemistry Biological Transport Biomedical and Life Sciences Biomedicine Carrier Proteins - genetics Carrier Proteins - metabolism Carrier Proteins - physiology Cell Biology Cellular biology Erythroid Cells - metabolism Gene Expression Regulation Hepatocytes - metabolism Hepatocytes - physiology Hepcidins Homeostasis Iron Iron - blood Iron - metabolism Life Sciences Macrophages - metabolism Macrophages - physiology Mammals Mammals - metabolism Membranes Mitochondria - metabolism Models, Biological Molecular biology Oxidoreductases - metabolism Oxidoreductases - physiology Review |
| title | Mammalian iron transport |
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